ae Oil. a pungent eccisie of tte ginger rhizome, hich foes not occur 
the oe: has. been isolated Hee in 1882 Py Thresh’) and was termed gingerol.. He 
— 
$ 
S or recent publications by H. Nomura*) and by A. Lapworth, “Li Kletz Pearson and 
onent of the rhizome, gingerol. a 
a small quantity of ether and shaken with 2 per cent. sodium hydroxide. From the 
then with water until the ee reaction apne atc: then dried over es 
after purification | by means of its bisulphite compound the m.p. 55 to 569; b.p. 186° 
car bonate solution yielded veratric acid (1), m.p. 180 to 181°. Ethylzingerone, when 
ae 
Oxi Jized with . warm alkaline sodium hypochlorite solution, gave ethylvanillic acid, we 
‘ ‘ae to 196°. The same oxidation of ences gave rise to Meratric: acid 
pound by means of “hydrogen in the piece: of platinum black to 4-hydroxy- 
; Ss, SaaS k 
tage ag ee eiap: (uy, 12 (1882), 721. — %) Ibidem 79 (1907), 118. — 4) Journ. Amer. chem, 
Soc 3 pee 16); 430. Pye: ‘also Pharmaceutical Journ. 98 (1917), Wiss - 4) Journ. chem. Soc. 111 (1917), 769. 
4 | ‘Thidem 717. — *) Berl. Berichte 49 (1916), 678. — 7) Comp. i. a Acres and G. eran, Gazz. 
N. ital ad (1908), i. 70; Chem. Zentralbl. 1908, Il. 1101. 
; denied ere ‘existence of Garnett and Grier’s gingerol, but erroneously, as is evident — 
7s ‘Nomura prepared. zingerone = Sibene better ginger rhizome with ether er: 
the cold and evaporating the extract to a syrupous consistency. The syrup was dissolved 
kaline solution the pungent principle was” deposited by means of carbon dioxide and. if 3 
Eracied with ether. The ethereal solution was washed with sodium carbonate solution, — 
a ‘yee 23 mm. pressure. The entire distillate iissotved: in ether gave with ee . - 
; hydrogen pane a double compound from. which Abeerone could be regenerated, ech ne 
ited at 40 to 42° and boiled at 204 to 205° (14 a) Metsicingerone, obtained i 
shaking ‘zingerone dissolved in sodium hydroxide with methyl sulphate showed 
(16 6 mm.); oxime, m.p. 93 to 93.5°. The methyl ether was identical with 3,4- dimethoxy- Fi 
~B zylacetone synthesised by A. Kaufmann and R. Radosevié').. Ethylzingerone melts cue 
t 66°, Oxidation of methylzingerone with potassium permanganate in hot diluted sodium | 
53 Royle’). ‘In both papers, the preparation of a pungent-tasting body of the formula s gag 
CaO, termed “zingerone”, from ginger rhizome is described.. By degradation, the: 
bod revealed itself as 4- -hydroxy-3-methoxyphenylethyl methyl ketone (I). Whereas - 
N are evidently believes zingerone to exist in the rhizome in the free state, Lapworth | a 
| his. co-workers prove that it is a — product of another pafecnt com- — 
