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- CHEMICAL PREPARATIONS 1 AND een : 67° 
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= Pierbine. Hdkatc. In his aiecassion of the German Pharmacopoeia 5t ed., 
G G. Frerichs* mentions among other things terpine hydrate, regarding the m.p. of which 
: e Pharmacopeeia states the following: “Terpine hydrate melts at 116° giving off 
Yv Seer. after which the m.p. sinks to 102°”. Frerichs says that terpine hydrate melts 
“at 102° only after having been heated long enough to lose all its crystallization water. 
The m.p. of 116° is only found when heating the terpine hydrate quickly. If the 
“indication of the Pharmacopeeia are followed exactly, by heating 1/2 minute for every 
esree of the ten last: degrees, the terpine hydrate loses part of the water already 
Z Bictore melting and then melts lower. He therefore proposes to say only: “Terpine 
hydrate melts, on being heated quickly, at 116° evolving steam bubbles”. 
e: - Terpineol. Recently, liquid terpineol has. been recommended?) as reagent in 
" microscopy. H. Sikora*) now describes its use for avoiding the shrinking of dry- 
_ conserved small preparations, such as gnats and flies. These objects are firstly fixed 
_ in van Leeuwen’s mixture, with omission of the picric acid, in some. cases also of the 
acetic acid; after some hours they are rinsed carefully in alcohol of 96 per cent., dried 
Bihoroushly in absolute alcohol and transferred as slowly as possible, by means of at 
east five intermediate solutions, into pure terpineol which is to be renewed repeatedly. 
A er prolonged immersion of some days’ or even weeks’ duration the preparations 
re dried in open air, which also takes days and weeks. They keep their shape and 
_ size even after eight months’ conservation without any shrinking.’ 
=> 
K. Slawiriski‘) reports on cis-trans-isomerism in the terpene series. He treated 
a “solution of terpineol in acetic acid with a 1 percent. solution of sodium hypo- 
enlorite and recrystallized the crystals separating from the reaction mixture after the 
addition of ether by means of a mixture of light petrdleum and acetic ester, and suc- 
~ ceeded in isolating two fractions of the m. p. 114° (b. p. 162 to 165° at 15mm.) and 
60 to 80° (b. p. 125 to 155°), respectively. Both bodies revealed themselves as the 
_ chlorohydrines of menthane-1/,2,8-triol. This mixture of chlorohydrines was treated 
ith caustic potash solution of 20 percent.. By extracting the reaction product with 
Petiier and with alcohol, a liquid and a crystalline part (m. p. 118 to 118,5°) were iso- 
&, lated. From the liquid portion, distillation yielded small amounts of pinol and pinol 
hydrate; the author believes the latter to originate solely from the cis-chlorohydrin of 
_ menthane- 1,2,8-triol. From the fraction of the b. p. 175 to 180° (13 mm.) there was 
4 obtained, by extraction with ether, cis-menthane-J, 2, 8-triol. The chlorohydrin of the latter- 
_ named body, m. p. 114 to 115°, yielded on treatment with 20 per cent. potash solution, 
Mezacly exclusively pinol hydrate. From the mixture of the chlorohydrines (m. p. 60 to 
2 - 80°), merely a small amount of the menthane-triol (m. p. 116 to 117.5°) could be iso- 
bea Hence, the trihydroxy compound originated from the lower-melting chlorohydrin. 
- H. J. Prins*®) demonstrates a simple process of the addition of water to terpineol 
a under the influence of acids. One c.c. of liquid terpineol was shaken in a. .test-tube 
ow ith 4 to 5c.c. of 80 per cent. phosphoric acid at 30°; after short standing the tube 
__ is filled with cold water, shaken again and left to stand. After a few minutes, terpin 
hydrate separates off in crystals. This addition, of water may be demonstrated also 
Be y aid of sulphuric acid of 60 per cent., but is not so complete as with phosphoric acid. 
3 ) 1) Apotheker Ztg. 32 (1917), 480. — 7) Comp. Report October 1910, 153. — *) Ztschr. f. wiss. Mikrosk. 34 
¥. 1918), 161; Chem. Zentralbl. 1918, 1. 771. — *) Chemik Polski 16 (1918), 97; Chem. Zentralbi. 1918, 1. 920. — 
_ *) Chem. Weekblad 14 (1917), 630. 
5* 
