préduce of the m. p. 139°, The latter is ‘gatahared’ aad identical 
some time ago by Cusmano and Linari) also from a-terpineol ni 
a round- about way; it proved to be a saturated oxime oxide be 
complicated manner. Evidently, there results a non- -crystailicite unsaturated 4 
oxime. Equally, the interaction of 8-terpineol nitrosochloride with alcohols is col 
cated. In presence of ethyl alcohol, the chlorine atom of the nitrosochloride is ar 
rently exchanged -for ethoxyl, thus yielding a rather unstable ethoxy! derivati 
With methyl alcohol, -terpineol nitrosochloride does not produce the correspondi 
methoxyl compound, but presumably a dihydroxyoxime. On hydrolyzing the varic b 
Saturated crystalline bodies resulting from the action of alcohols on é-terpineol 
‘nitrosochloride, there results in all cases the same body CiHu0O, a ketone, the 
semicarbazone of which melts at 218°. The identical ketono is ‘obtained - a 
hydrolizing the unsaturated oxime (resulting by interaction of 6-terpineol nitroso 
chloride with sodium methoxide or with pyridine) by means of sulphuric | aci 
whereas the oxime, on heating with oxalic acid, produces an aldehyde-like bod 
CioHi,0, the semicarbazone of which melts at 209°. 
MN 
Thymol. Evidently, ajowan seed is now used for producing thymol in ‘Britis 
India, instead of in Europe, as was the case before the war. We find in an Englis 
periodical *®) the reproduction of a photo, taken in Calcutta, of a 1916 Ibs. lot of ee 
intended for New York and London. e 
On former occasions, we have pointed out that nothing had candeien ‘so ) far, as! 4 
to the properties of the thymol produced in England or British India; in fact, not so 
very long ago the English had not yet succeeded in this simple manufacture, for. the 
product obtained did not come up to the requirements of the British Peete | 
As to the possibility of obtaining thymol from the oil ‘of cian viride, see P. 36 ! 
of this Report. ‘al 
According to H. Elion®), the method for determining thymol, salicylates and stint 
bodies, described as new by A. Seidell*), and according to which the absorption 
bromine is measured, was known long ago and published by him in 1888 ye: 
G. A. Prins®) calls attention to the poisonous action of thymol. It nee pas 
as inoffensive, however, Leichtenstein witnessed a fatal case of poisoning after th 
administration of 6 grams of thymol. In other cases, less severe symptoms of poison in; 
vomiting, stomach-ache, colic, etc. were observed after taking big doses’). T 
being used in quantities of 0.5 to 1.5 g. daily, caution is advisable. 
remembered that thymol is contained in numerous dentifrices as well as” in 
modern remedies, such as Pyrenol, Archovin, Pertussin, ca Thym ) 
Thymoform and Aristol. “i 
1) Chem. Zentralbl. 1912, 1. 1012; Report October 1912, 167. — 2) Chemist and Druggist 90 
*) Journ. American chem. Soc. 89 (1917), 1513. — *) American chem. Journ. 47 (1912), 508; _ Report Oc 
— °) Recueil trav. chim. of the P.-B. ll. 7 (1888), 211. — *) Ned. Tijdschr. v. Geneesk. 19: 
Weckblad. — According to Apotheker Ztg. 38 (1918), 132. — 7) There. are no- indications as 
the doses. Se, ) oy 
