100 Report of Schimmel § Co. April/October 1917. 



1 c.c. of the dilution of 1 in from 5 to 10 millions, the final dose in most from 1:20000 

 to 1 : 2000, from which it results that it had generally been possible to raise the dose 

 1200 fold in the course of an uninterrupted treatment. The sensitiveness of the eyes 

 sank at the same time to from one tenth to one twentieth of what it had been, so 

 that it can only serve as a criterion for the initial dose, whereas after repeated injections 

 the clinical reaction of the previous injection only can serve as a guide for the deter- 

 mination of the fresh dose. The injections were sustained well, on a whole. The local 

 reaction after the injection generally kept within moderate limits, was gone as a rule 

 after 1 to 3 days, and lessened in intensity from injection to injection. General symp- 

 toms were noticed only once with a highly sensitive lady patient, who, half an hour 

 after the injection, got a violent itching of the skin all over the body, a rash on neck 

 and arms, swelling of the face, and experienced difficulty in breathing; however, these 

 symptoms had gone the next morning. At the same time, the limit of sensitiveness 

 had risen again from 1:500000 to 1:1000000. 



In order to judge of the clinical success, two of the eight cases treated must 

 be left out of consideration, as the treatment had to be interrupted after two and 

 eight injections, respectively. Three of the remaining ones called special attention, 

 owing to their having been treated already by Dunbar in 1912, two with good, and 

 the third with less success. One of these three persons was treated again in 1913 

 and 1914; the second in 1913, and the third in 1914. With the first lady patient, who 

 was highly sensitive and anaphylactic towards horse and rabbit sera and who had 

 undergone the treatment three times, the specific therapeutics caused no improvement 

 worth mentioning, so that this case had to be booked as a failure. The results obtained 

 with the other five persons, however, were rather satisfactory. One of the cases, 

 immunized for the second time in 1913, was specially successful, as the patient was 

 almost free of his old complaint without any treatment in summer 1914. 



Summarily speaking, the value of active immunization causes in many patients an 

 unmistakable alleviation of the attacks of hay-fever and, in some cases, seems to lead 

 to an almost complete cure of it. However, according to the experience gathered up 

 to now, the hope to attain a lasting immunity through the injection, has only been 

 partly realized. One ought, therefore, to beware of overrating the treatment, which, 

 by the way, highly taxes the patience of the patients. On the other hand, however, 

 the observations made entitle us to recommend, in appropriate cases, the treatment 

 of the complaint through active immunization. 



Thymol. On page 78 of our last October Report, we discussed the Bulletin N° 372 

 of the U. S. Dep. Agric. by S. C. Hood according to an abstract in the American Journal 

 of Pharmacy. As we now have the original paper at our disposal, we seize the op- 

 portunity to supplement our first communication. 



Monar da punctata often only developes very few leaves which reduces the oil yield 

 to a great extent. By means of selection, Hood succeeded in obtaining a larger and 

 lighter coloured plant which produces more leaves and also grows to a greater height. 

 It contains about 0.42 per cent, of oil with 74 per cent, of phenols, whereas the original 

 plants in the first year supplied 0.17 and in the second 0.24 per cent, with a phenol 

 content of 64 per cent. 



In the South-eastern states of North America the seeds of Monarda punctata mature 

 in August and September. In the extreme South-eastern states, where no severe frost 

 nor heavy snowfalls are to be feared during winter, sowing can be done already in 

 November. The most suitable soil for this cultivation is light, calcareous and sandy 



