EXPERIMENTS ON GUINEA PIGS. 



19 



ments. This disappearance of caffein from the stomach and intestines 

 may be due to bacterial decomposition or to reabsorption. But since 

 caffein is known to resist putrefactive changes, absorption from the 

 gastrointestinal tract and decomposition in the tissues must be 

 assumed, which may account for the smaller percentage amounts of 

 caffein found at the end of forty-eight hours. 



Series X. — Guinea pigs, 100 mg per kilo of caffein injected, 24-hour period. 



No. and diet. 



Weight. 



Food 

 con- 

 sumed. 



Water. 



Excreta. 



Caffein recovered 

 from composite 

 samples. 



Initial. 



Final. 



Urine. 



Feces. 



Urine. 



Gastro- 

 intestinal 

 tract. 



Carrots: 

 150 



Grams. 

 620 

 560 

 555 



Grams. 

 560 

 525 

 535 



Grams. 



None. 



50 



40 



cc 



None. 

 40 

 20 



cc 

 45 

 60 

 60 



Grams. 

 None. 

 None. 

 None. 



Per cent. 



Per cent. 



151... 



8.43 



2.65 



152 









Total . 







90 



60 



165 





11. 08 













Oats: 

 153 



375 

 430 

 365 



355 

 405 

 345 



10 



10 



None. 



10 



10 



None. 



15 

 10 

 10 



10 

 10 

 10 







154 



4.84 



5.0 



155... 









Total 







20 



20 



35 



30 



9.84 













Series XI. — Guinea pigs, 100 mg per kilo of caffein injected, 48-hour period. 



No. and diet. 



Time. 



Weight. 



Food 

 con- 

 sumed. 



Water. 



Excreta. 



Caffein recovered 

 from composite 

 samples. 



Urine. 



Feces. 



Urine. 



Gastro- 

 intestinal 

 tract. 



Carrots: 



Hours. 

 f Initial. 



24 

 I 48 

 f Initial. 



24 

 1 48 

 f Initial. 



24 

 I 48 



Grams. 

 430 

 385 

 365 

 440 

 415 

 415 

 425 

 395 

 400 



Grams. 



cc 



cc 



Grams. 



Per cent. 



6.36 

 1.56 



Per cent. 



162 







20 

 10 

























157 



40 

 75 





20 

 50 













5 



0.5 









158 



50 

 100 



10 



40 

 65 



10 

 10 















Total 







265 



10 



205 



25 



8.42 











Oats: 



f Initial. 



24 

 I 48 

 1 Initial. 



24 

 1 48 

 f Initial. 



24 

 I 48 



625 

 600 

 590 

 720 

 670 

 650 

 840 

 775 

 755 











5.00 

 .55 





159 



15 

 5 



10 

 15 



15 

 20 



15 

 10 









160 







20 

 20 



10 













0.50 













161 





20 

 15 



55 

 25 



10 







20 











Total 







40 



60 



155 



45 



6. OS 













