EXPERIMENTS ON RABBITS. 15 



Series IV. — Rabbits to which 50 mg caffein per kilo were administered subcutaneously . 





Weight. 



Urine data for — ■ 



Rabbit No. and diet. 



3 hours. 



24 hours. 



72 hours. 





Volume. 



Caffein 

 recover- 

 ed. 



Volume. 



Caffein 

 recover- 

 ed. 



Volume. 



Caffein 

 recover- 

 ed.^ 



Oats: 



658 



Grams. 

 1,650 

 1,445 

 1,650 



1,655 

 1,745 

 1,625 



cc 

 20 

 30 

 60 



2 75 

 268 

 2 60 



Per cent. 

 1 1.20 



1 2.70 



cc 



f 75 

 \ 80 



I 55 



f 410 

 \ 260 

 I 240 



Per cent. 

 { 0.52 



\ 4.48 



cc 

 f 95 

 { 95 

 I 95 



f 320 

 { 400 

 { 350 



Per cent. 

 ) 



657 



^Trace. 



651 



j 



Carrots: 



621 



1 



638 



>None. 



639 



) 







Total recovery for oat fed rabbits 1.72 per cent, for carrot fed 7.18 per cent. 

 In 2 hours. 



Series V. 



Series V. — Rabbits receiving 50 mg per kilo of caffein. 



Rabbit No. and diet. 



Weight. 



Time. 



Food 

 con- 

 sumed. 



Water. 



Volume 



of 

 urine. 



Caffein recovered 



from composite 



sample. 





Time. 



Amount. 



Oats: 



Grams. 

 2,265 



2,480 



1,620 



Hrs. 

 f 3.5 



24.0 

 1 48.0 

 { 72.0 

 f 3.5 



24.0 

 1 48.0 

 I 72.0 

 f 3.5 



24.0 

 1 48.0 

 I 72.0 



Grams. 



cc 



cc 

 40 

 45 

 35 

 45 

 100 

 95 

 80 

 80 

 20 



Lost. 

 30 

 15 



Hrs. 



3.5 

 24.0 

 48.0 

 72.0 



Per cent. 



724 



100 

 125 



45 



140 

 100 



None. 







3.00 



725 



95 

 80 



75 



200 

 100 



100 



2.33 

 Trace. 



None. 





726 



65 

 75 

 50 



135 



100 

 100 





Total 



5.33 

















Carrots: 



1,900 

 1,740 

 2,030 



f 3.5 

 I 24.0 

 I 48.0 

 1 72.0 

 f 3.5 

 1 24.0 

 | 48.0 

 { 72.0 

 f 3.5 

 1 24.0 

 1 48.0 

 I 72. 







1 



55 

 275 

 220 

 165 



75 

 240 

 270 

 265 



85 

 230 

 250 

 250 



3.5 

 24.0 

 48.0 



72.0 





727 ! 



500 

 500 



400 



None. 



30 



None. 







3.55 



728 1 



500 

 500 

 500 



None. 

 None. 

 None. 



7.83 





Trace. 

 None. 



729 



500 

 500 



500 



None. 

 None. 

 None. 





Total 



11.38 



















1 Small amount of feces excreted by these rabbits, probably not over 50 grams during the entire experi- 

 ment; there was no diarrhea whatever. 



The enormous difference in the amounts of caffein eliminated on 

 the diets employed in the last series made the repetition of these 

 experiments necessary. Although considerably more caffein was 

 excreted on an oat diet than in Series IV much less was recovered 

 than in the parallel experiments when feeding carrots. It will be 

 noticed also that the appetite was not impaired and that much larger 

 amounts of urine were passed when carrots were eaten. 



