250 Proceedings of the Royal Physical Society. 
the line of junction between this typically ovarian pigment and the normal 
spermatic tissues was very irregular. 
Left gonad. Structure as that of the gonad of the opposite side save that 
degenerate ova were found amid the pigment (Fig. 21). 
Pituitary and suprarenals normal in size and structure. Cilated 
epithelium upon the suspensory ligaments of the gonads. | 
GENERAL DISCUSSION. 
It is convenient to discuss the abnormalities as they affect the primary 
and the secondary sexual characters. ‘ 
I.— PRIMARY SEXUAL CHARACTERS. 
A. The promary sex-glands or gonads. 
In all seven cases both ovarian and spermatic tissue were present in the 
gonads. The relative amounts of the two varied. In Cases Nos. I. and IL, 
ovarian tissue constituted the whole of one gonad and the greater part of the 
other: in Cases Nos. IV., V., VI. and VII., spermatic tissue preponderated 
in both gonads. 
In every case without exception, the spermatic tissues were healthy and 
of normal appearance, whereas the ovarian tissues exhibited some degree of 
i i i 
degenerative change. 
With the possible exception of Case No. L, in which the exact position } 
of the spermatic tissue is not definitely known, in every gonad in which both 
tissues were obviously present, the spermatic was situated upon the inner 
border of the gonad, or in these cases in which the spermatic tissues formed 
the greater part of the gonad, then the ovarian tissues were placed upon the 
outer border of what appeared to be an abnormal testis. This is the position 
in which the vasa efferentia could effect a connection between testis and 
kidney most readily. 
Apparent increase in the amount of the normal pigment of the ovary 
was invariably associated with the presence of pathological changes in the 
ovarian tissues. In one gonad of Case No. VII. all that remained of the 
ovarian tissues was the pigment. 
The proof that this abnormal pigment is ovarian can be supplied by 
microscopical examination. Upon the animal pole of a mature ovum, the 
essential product of the female, are polygonal masses of pigment, of constant 
shape and intrinsic origin (Fig. 21). Upon the peritoneal investment of a 
pigmented testis are branched chromatophores, pigment cells of character- 
istically elongated shape, which, lying in the superficial grooves, outline the 
