48 M. ADEIEN LOIR. LARGE DEATH RATE AMONG AUSTRALIAN 



like the same extent as if they had been long on the road, and had 

 been weakened from want of grass and water and over-driving. 



On the following day (6th October), at 2 p.m., one of the 

 inoculated sheep died ; at 4 p.m. another of these sheep died ; at 

 6*30 a.m. of the 7th October, another inoculated sheep died ; and 

 at 7" 30 a.m. of that date the fourth and last inoculated sheep died. 

 From this it will be seen that the two first deaths occurred within 

 a shorter time than those of any of the other sheep which died of 

 inoculation with virulent virus during the demonstration, and 

 that the average period of inoculation of the whole four sheep — 

 thirty-three hours — is considerably less than that of the other 

 inoculated sheep ; and the result, indicates that the supposition 

 may be taken as correct, that conditions favourable to a speedy 

 development and termination of the disease being given — such as 

 fever, starvation, and exhaustion — surprise need not be occasioned 

 if deaths occur among travelling sheep within twenty hours of 

 their coming on infected ground. 



Some months back M. Charrin of the Institute Pasteur in Paris, 

 investigated the action produced by fatigue on the evolution of 

 Cumberland Disease. The animals experimented upon were white 

 rats, which are not very susceptible to the virus. A number of 

 rats having been inoculated with Cumberland Disease, some of 

 them were allowed to remain in repose while the others were sub- 

 jected to an " over-driving " process consisting of placing them in 

 a cylinder one metre in diameter, and similar to those sometimes 

 placed in squirrel's cages. The cylinder turned on its axis ten 

 times a minute, and the animals which were shut up in it were 

 compelled to walk in a direction opposite to that of the motion 

 applied to the cylinder, and they walked thus a distance of 2,260 

 metres an hour. The fatigue imposed upon these inoculated 

 animals produced an effect favourable to the infection, and the 

 exhausted animals always died before those which were allowed 

 to remain in a state of repose. 



It is therefore conclusive that in the case of Cumberland 

 Disease, as in many other diseases, exhaustion favours the develop- 



