PERSISTENCE OF PENICILLIN IN MILK 
After One Udder Infusion 
VEHICLE DOSE: 100,000 UNITS 
Water References: 17, 33, 36, 37, 55 
j 
Bougie 
Water -in- oil 
emulsion 
Ointment 29, 33, 34, 51, 53 
| 
Oil 10, 15, 26, 30, 33, 36, 37, 
DOSE 
100,000 units 
300,000 units 
10 12 14 16 18 
DAYS AFTER INFUSION 
U. S. DEPARTMENT OF AGRICULTURE AGRICULTURAL RESEARCH SERVICE 
BN- 10709-X 
Figure 1,--Udder infusion: The effect of vehicle and dose on the persistence of penicillin in milk, 
PERSISTENCE OF PENICILLIN IN MILK 
After One Udder Infusion 
PRODUCTS MAXIMAL . 
eeu MAXIMAL DOSE: 100,000 UNITS IN OIL BASE VEHICLES 
0.25-0.50 References: 17,84 
0.08 
0.01—4.00 
< 0.06 
<0.06-0.14 
< 0.03 
0.04-0.06 
0.12 
0.04 
0.03 
0.04 
0.05-0.07 
DAYS AFTER INFUSION 
U. S. DEPARTMENT OF AGRICULTURE AGRICULTURAL RESEARCH SERVICE 
BN- 10708-X 
Figure 2,--Udder infusion; The maximal time penicillin persisted in milk when various oil base vehicles 
(water-in-oil emulsion, ointment, mineral or peanut oil) were used, The maximal units per ml, refer tothe 
concentration when last detected in milk, 
192 
