Table 23. — Liver weights in jasted and nonfasted rats maintaining weight at different ages on stock, SP 8 



HVO, and SPE diets 



Condition, diet, and 

 age (days) 



Rats 



Average 

 age 



Average 

 weight 



at 

 death » 



Liver weight 



Average 



Range 



Liver to 



body 

 weight 



Rats with livers weighing — 



Less 



than 



10. 



grams 



10.0 to 

 14 9 



grams 



15.0 to 

 19. 9 



grams 



20. 



grams 



and 



over 



Fasted rats 



Stock: 



Less than 200 



200 to 299 



300 to 399 



400 to 499 



500 and over 



SP8HVO: 



200 to 299 



300 to 399 



400 to 499 



500 to 599 



SPE: 



200 to 299 



300 to 399 



400 to 499 



500 to 599 



Nonfasted rats 



Stock: 



Less than 200 



200 to 299 



300 to 399 



400 to 499 



500 to 599 



600 and over 



SP 8 HVO: 



Less than 200 



200 to 299 



300 to 399 



SPE: 



Less than 200 



200 to 299 



300 to 399 



Number 

 4 

 15 

 6 

 5 

 7 



6 

 8 



7 

 14 



1 t 

 1 1 



L5 



11 

 5 



- 

 l 1 

 11 



5 



6 



23 



5 



18 

 25 



Days 

 160 

 248 

 382 

 436 

 723 



252 

 353 

 457 

 546 



252 

 348 

 455 

 530 



148 

 258 

 376 

 465 

 538 

 679 



154 



248 

 332 



154 

 277 

 331 



Grams 

 381 

 447 

 428 

 436 

 405 



502 

 541 

 600 

 680 



552 



588 

 616 

 624 



390 

 466 

 482 

 4S6 

 490 

 457 



521 

 532 

 636 



520 

 613 

 617 



Grams 

 9. 6 

 11. 5 

 11. 7 

 11. 2 

 10.7 



11. 



12. 



13. 4 



14. 3 



18.2 

 23. 6 

 21. 7 

 20. 



13. 3 



15. 1 



16. 8 



17. 7 



18. 6 

 18.7 



23.7 

 18.7 

 20. 



22 

 oo 



7 

 4 

 29. 9 



Gra ms 

 8. 3-10. 2 

 8. 3-14. 3 



8. 6-16. 1 



9. 1-12. 2 



8. 7-13. 6 



9. 1-13. 9 

 9. 6-14. 1 



10. 1-18. 2 

 10. 8-17. 9 



12-8-24. 3 

 18. 2-30. 1 

 14. 3-31. 8 

 13. 5-26. 6 



9. 4-15. 8 



12. 0-17. 8 

 14. 2-21. 7 

 14. 4-25. 9 



13. 0-26. 9 

 11. 7-21. 7 



21. 2-30. 7 



14. 3-27. 2 

 14. 6-26. 3 



19.2- 



1 



21. 8-36. 4 

 20. 0-48. 1 



Percent 

 2. 5 

 2. 6 

 2. 6 

 2. 5 

 2. 4 



2.2 



2. 2 

 2. 2 



2. 1 



3. 3 

 3. 9 

 3.5 

 3. 1 



3.4 

 3.2 

 3. 4 

 3. 6 



3. 7 

 3.9 



4. 5 

 3.5 



3. 1 



4.3 



4. 6 



4.8 



Percent 

 50 

 20 

 33 



43 



33 



12 

 

 







II 

 II 







87 

 46 

 20 

 29 

 18 

 9 







17 

 9 





 



it 



Percent 

 50 

 SO 

 50 



si I 

 57 



67 



88 



71 

 71 



1 1 

 

 7 

 9 



l.: 

 54 

 60 

 57 

 46 

 54 





 50 



39 



20 

 

 



Percent 

 

 ii 

 17 

 

 



II 





 29 

 29 



71 

 12 

 29 

 46 







ii 



LM) 



14 

 36 

 36 



80 

 33 

 52 



80 

 72 

 60 



Percent 

 

 

 

 



(I 







I) 

 II 







14 

 88 

 64 

 46 





 

 

 

 

 



20 







II 







28 



40 



1 Weight before 17-hour fast. 



grams for the largest. No consistent trend with 

 age was noted except for the larger percentage of 

 rats less than 300 days old with livers weighing 

 less than 20 grams. 



The livers from nonfasted rats fed SPE diet 

 averaged 28.6 grams in weight and represented 4.7 

 percent of body weight. For rats less than 200 

 days old, livers were large in comparison to those 

 from rats fed the stock diet but similar in size to 

 those from comparable SP 8 HVO rats. The 

 largest livers obtained with stock, SP 8 HVO, or 

 SPE rats were from nonfasted SPE rats 200 to 399 

 days old. 



Correlation coefficients. — The data in ta- 

 bles 22 and 23 show that the factors affecting 

 kidney weight generally exert a parallel influence 

 on liver weight. In figure 8 are seen the lines ob- 

 tained from the regression equation expressing the 

 relationship between kidney and liver weights of 

 fasted and nonfasted rats fed stock diet as well as 



the data for individual rats. Food intake imme- 

 diately before sacrifice was not controlled for the 

 nonfasted rats and undoubtedly accounts, in part 

 at least, for the greater variation in the relationship 

 observed for these rats. 



For any one diet, liver and kidney weights 

 tended to parallel body weight, and variations in 

 body weight within age groups seemed to account 

 in part for the wide range of values observed in the 

 weight of these organs. Consideration of the indi- 

 vidual data, however, indicated that the close 

 parallelism between liver and kidney weights was 

 not due entirely to the relation of the weight of 

 these organs to body weight. In table 24 are sum- 

 marized, for rats fed stock and SP 8 HVO diets, 

 data relating liver to kidney weight and these 

 organs to body weight. Correlation coefficients of 

 0.84 to 0.88 were obtained relating liver and kidney 

 weights of fasted and of nonfasted rats fed these 

 two diets. Correlation coefficients relating liver 



40 



