KIDNEY WEIGHT" 

 (grams 



Regression equation 

 y=0.29 + 0J!3x 



o Regression equation: 

 y=0. 052 + 0. !09x 



JL 



8 



12 



16 



20 



24 



26 



LIVER WEIGHT (grams) 



Figure 8. — Liver weight in relation to kidney weight in fasted and nonfasted rats fed stock diet. 



or kidney weight to body weight tended to be 

 lower than those for liver and kidney, although for 

 fasted rats the differences observed were generally 

 small. The lowest correlation coefficients were 

 those relating liver or kidney to body weight in 

 nonfasted rats fed the semipurified diet. 



There was little evidence for a quantitative rela- 

 tionship between liver and kidney weights or be- 

 tween these organs and body weight in rats fed 

 SPE diet. Even in fasted rats, ratios for liver to 

 kidney weight varied from 3.4 to 15.5. 



Kidney weight of animals losing weight 

 on stock, SP 8 HVO, and SPE diets. — In table 

 25 are summarized data on the kidney weights of 

 fasted and nonfasted rats that were fed stock, SP 8 

 HVO, or SPE diets and were losing weight when 

 sacrificed. The results for rats losing less than 

 100 grams have been separated from those for 

 rats losing over 100 grams in weight. 



When weight loss was less than 100 grams, 

 the kidneys from fasted rats fed stock or SP 8 

 HVO diets were similar in size to those from rats 

 of comparable age that were maintaining weight 

 on these diets. On SPE diet, however, large 

 kidneys were observed even in young rats, and in 

 animals 400 to 599 days old 68 percent of the 

 kidneys weighed more than 4 grams. When weight 

 loss exceeded 100 grams, the kidneys from fasted 

 rats tended to be larger with all three diets than 

 did those from comparable animals with little or 



no weight loss. The largest kidneys were from 

 rats fed SPE diet. 



The tendency of the nonfasted rats to have 

 larger kidneys than the fasted animals was 

 apparent among those that were losing weight, 

 as well as among those maintaining weight, 

 although the differences were small for older SPE 

 rats when exceedingly large kidneys were found. 

 In nonfasted rats losing more than 100 grams, 

 kidneys were large at all ages regardless of diet; 

 kidneys from SPE rats tended to be larger than 

 those from animals fed stock or SP 8 HVO diets. 



Liver weight of animals losing weight on 

 stock, SP 8 HVO, and SPE diets.— In table 26 

 are summarized data for the liver weights of rats 

 that were losing weight on stock, SP 8 HVO, or 

 SPE diets. In general, the results for rats losing 

 less than 100 grams were similar to those for 

 comparable rats that were maintaining weight 

 except for the tendency to smaller livers in young 

 nonfasted rats fed SP 8 HVO diet. When weight 

 loss exceeded 100 grams, the difference between 

 the liver weights of fasted and nonfasted rats 

 became small, reflecting the reduced food intake 

 of these animals. The livers from SPE rats were 

 consistently larger than those from rats fed stock 

 or SP 8 HVO diets. The marked increase in 

 kidney weight that has been seen to occur with 

 increasing loss in body weight was not accom- 

 panied by a parallel increase in liver weight. 



41 



