Table 26. — Liver weights in jasted and nonfasted rats losing weight at different ages on stock, SP 8 HVO, 



and SPE diets 





Rats 



Average 

 age 



Liver weight 





Rats with livers weighing — 





Weight loss, condition, diet, 

 and age (days) 



Average 



Range 



Less 



than 



10.0 



grams 



10.0 

 to 14.9 



grams 



15.0 to 



19.9 



grams 



20.0 to 

 29.9 



grams 



More 



than 



30.0 



grams 



Rats losing less than 100 

 grams: 

 Fasted rats: 

 Stock: 



Less than 500 



Number 



Days 



Grams 



Grams 



Percent 



Percent 



Percent 



Percent 



Percent 



500 and over 



6 



7 

 9 



19 



22 



6 



1 



8 



10 

 5 



11 

 6 



2 



712 



295 

 645 



296 

 489 

 643 



456 



787 



375 

 619 



315 



489 

 608 



12. 5 



9.4 

 12. 4 



16. 1 

 20. 7 

 19. 6 



10.3 



19. 3 



14. 3 



20. 1 



25. 4 



26. 7 

 43. 1 



10. 7-15. 5 



6. 5-11. 7 

 9. 1-15. 4 



7. 6-26. 



15. 9-27. 



16. 5-25. 6 



10.3 



14. 6-24. 1 



10. 0-23. 



14. 0-24. 7 



15. 0-38. 7 

 15. 1-38. 9 

 33. 6, 52. 6 







57 

 11 



16 

 

 





 





 





 

 



83 



43 



78 



37 

 

 



100 

 12 



70 

 20 





 

 



17 





 11 



21 

 50 



67 





 50 



20 

 20 



18 



33 













 



26 

 50 

 33 







38 



10 

 60 



55 



33 











SP 8 HVO: 



Less than 500 



500 and over. _ 





 



SPE: 



Less than 400 

 400 to 599 





 



600 and over -_ _ 







Nonfasted rats: 

 Stock: 



Less than 500 

 500 and over 





 



SP 8 HVO: 



Less than 500... 

 500 and over . 





 



SPE: 



Less than 400 



400 to 599 



27 

 33 



600 and over _. _ 



100 



Rats losing more than 100 

 grams: 

 Fasted rats: 

 Stock: 



Less than 500 _ _ 





500 and over. 



4 



3 

 4 



7 



22 



7 



4 



7 



2 

 20 



13 



25 



5 



682 



419 

 654 



376 

 504 

 644 



411 

 695 



426 

 695 



339 



482 

 643 



15.4 



14. 7 

 13.8 



21. 2 

 19. 7 

 16. 5 



19. 8 

 16. 6 



14. 7 

 16. 



20.5 

 20.5 



20. 2 



11. 9-18. 2 



13. 1-18. 



13. 8-14. 



14. 0-30. 2 

 14. 7-27. 5 

 14. 3-19. 8 



14. 0-23. 1 

 14. 6-19. 4 



14. 2, 15. 2 

 10. 8-22. 4 



16. 4-24. 1 

 14. 3-40. 1 

 16. 1-26. 9 









 





 

 





 





 





 

 



50 



67 

 100 



14 



5 



28 



25 

 29 



50 

 35 







8 

 



50 



33 

 



43 

 55 



72 





 71 



50 

 50 



38 

 48 

 60 









 



29 



41 







75 

 





 15 



62 

 40 

 40 







SP 8 HVO: 

 Less than 500 

 500 and over 



SPE: 



Less than 400. _ 



400 to 599. _ . 





 



14 

 



600 and over 







Nonfasted rats: 

 Stock: 



Less than 500 . . 

 500 and over 





 



SP 8 HVO: 



Less than 500 . 

 500 and over . . 





 



SPE: 



Less than 400 

 400 to 599-.. 





 4 



600 and over 











Kidney weight and damage. — Table 27 shows 

 the relation of kidney size to the histological find- 

 ings. Because of the influence of fasting on the 

 size of this organ, the results of fasted and non- 

 fasted rats are reported separately. For both 

 fasted and nonfasted rats, a gradual increase in 

 kidney damage with increasing kidney weight was 

 observed with all three diets. Kidneys weighing 

 less than 1.8 grams were generally normal in 

 appearance. The only evidence of degenerative 

 changes in kidneys weighing 1.8 to 2.0 grams was 



the presence of a few hyalin casts. When kidneys 

 weighed between 2 and 3 grams, more extensive 

 damage was apparent, with glomerular damage 

 occurring in many of the kidneys from stock rats. 

 Kidneys weighing more than 3 grams generally 

 showed evidence microscopically of all three types 

 of damage regardless of diet, but the ratings for 

 glomerular damage were consistently greater for 

 rats fed the stock diet. 



Liver weight, liver fat, and kidney dam- 

 age. — The weights of livers from rats fed the 



48 



