Table 27. — Kidney weight as related to kind and extent of damage in fasted and nonfasted rats fed stock, 



SP 8 HVO, and SPE diets 



Condition, diet, and range of kidney weight (grams) 



Rats 



Average 

 kidney 

 weight 



His 



tological rating 





Hyalin 



Cystic 



Glomerular 



Fasted rats 



Stock: 



Less than 1.S0. __ . _ _ 



Number 

 25 



2 



7 

 1 



34 

 7 

 6 

 3 

 1 



23 

 10 

 25 

 16 

 43 



34 



10 



23 



9 



2 



12 



7 



12 



11 



5 



7 



5 



21 



13 



40 



Grams 

 1. 44 



1. 89 



2. 31 

 2.75 



1. 44 



1. 89 



2. 38 

 4. 12 

 8.67 



1.55 

 1.87 



2. 53 

 4. 22 

 7.44 



1.47 

 1.90 

 2.38 



3. 57 

 7.02 



1. 62 



1. 90 



2. 34 



4. 18 

 6. 82 



1. 70 



1. 87 



2. 28 



3. 77 

 8.52 



Score 



0. 1 



1. 

 1.9 



4. 



. 2 



. 7 



1. 2 



2.3 



3.0 



.6 



1. 1 

 2.0 

 2.5 



2. 4 



. 1 

 . 7 



1. 4 



3. 



2. 



. 4 



. 6 



1. 2 



2.6 



3.6 



. 6 

 1. 

 1.2 

 2.5 

 2.4 



(Score 

 

 



.9 

 2.0 





 



. 2 

 2.0 

 4.0 





 

 . 5 

 1.9 



3. 4 







. 1 



.7 



2. 



4.0 





 



.2 

 2.2 

 3.0 





 

 

 1.2 



3.5 



Score 

 



1.80 to 1.99 ._ ._ . 







2.00 to 2.99__. ....__ 



1.4 



3.00 to 4.99 ._ . . . . 



3.0 



SP 8 HVO: 



Less than 1.80. . ._ . . 







1.80 to 1.99 







2.00 to 2.99 .. ._ 



. 2 



3.00 to 4.99 - _ _ ... 



2.3 



5.00 and over _____ 



2. 



SPE: 



Less than 1.80 ______ _ _ __ 







1.80 to 1.99 ._ _ 



. 1 



2.00 to 2.99._ __ 



.2 



3.00 to 4.99 . 



1. 5 



5.00 and over _ _____ 



2.0 



Nonfasted rats 

 Stock: 



Less than 1.80 _ _ _ 







1.80 to 1.99 







2.00 to 2.99 



. 7 



3.00 to 4.99 __ _ ___ 



2.9 



5.00 and over _ 



3.0 



SP 8 HVO: 



Less than 1.80 _____ _ _ 







1.80 to 1.99 . 







2.00 to 2.99 



. 2 



3.00 to 4.99__ __ _ . 



1. 8 



5.00 and over _ _ _ _ _ 

 SPE: 



Less than 1.80 



2. 4 

 



1.80 to 1.99 __ _ _ _ ._ 







2.00 to 2.99-.. . 



. 1 



3.00to4.99_ _ . 



1.4 



5.00 and over _ . _ 



2.2 







stock diet also paralleled closely the extent of the 

 damage observed in the kidneys. In table 28 

 are summarized data from nonfasted stock rats 

 that were maintaining their body weight. Little 

 evidence of kidney damage was observed in these 

 rats when livers weighed less than 16 grams; ex- 

 tensive damage was found when livers exceeded 

 20 grams in weight. There were too few data to 

 establish a comparable relationship in the fasted 

 rats, and in moribund rats this relationship was 

 complicated by variable weight loss. 



In nonfasted rats fed SP 8 HVO diet, larger 

 livers were not necessarily accompanied by 

 damaged kidneys. No evidence of kidney damage 

 was apparent in the group of five rats 150 days 

 of age, although three of the livers from these 

 rats weighed more than 20 grams. 



On SPE diet no consistent relation was found 

 between kidney damage and liver size or between 

 size of liver or fat in the liver as seen microscopi- 

 cally. A liver weighing 13.5 grams showed 

 evidence of fat in amounts comparable to that 



Table 2S. — Liver weight as related to kind, and extent 

 of kidney damage in nonfasted rats maintaining 

 weight on stock diet 



Liver 





Aver- 



Histological 



rating 



weight 



Rat 



age 

 liver 









range 









(grams) 





weight 



Hyalin 



Cystic 



Glo- 

 merular 





Num- 













ber 



Grams 



Score 



Score 



Score 



Less than 14.0 



15 



12. 5 















14.0 to 15.9__- 



18 



14.9 



. 1 











16.0 to 17.9 __ 



11 



17. 



. 9 











18.0 to 19.9 __ 



6 



18. 6 



1. 



.3 



.3 



20.0 and over. 



10 



22. 8 



2. 1 



1. 2 



1. 6 



seen in livers weighing 25 grams. Fat was 

 apparent at an early age before kidney damage 

 occurred, and was seen in all but one of the livers 

 from rats with normal kidneys. As kidney 



44 



