Table 32. — Kidney and liver weights of fasted and nonfasted rats maintaining or losing weight on diets 



containing different kinds and levels of fat 



Condition, weight status, and diet 



Rats 



Average 

 age 



Average 



weight 



loss 



Kidney weight 



Liver weight 





Average 



Range 



Average 



Range 



Nonfasted rats 



Maintaining weight: 



SP 8 HVO - -- _ _-- 



Number 

 5 

 5 



5 



4 

 6 

 2 

 4 

 5 



7 

 2 



6 



5 

 4 

 1 



Days 

 184 

 186 



703 

 700 

 632 

 695 

 605 

 554 



587 

 636 

 493 

 555 

 591 

 404 



Grams 

 

 



53 

 54 

 48 

 94 

 32 

 56 



151 

 152 

 163 

 138 

 152 

 147 



Grams 

 1. 95 

 1. 83 



1. 61 



1. 77 



2. 78 

 2. 84 

 2. 15 

 2.65 



4.50 



4. 94 



5. 12 

 4. 04 



4. 02 



5. 10 



Grams 

 1. 76-2. 54 

 1. 64-2. 48 



1. 46-1. 69 

 1. 32-3. 45 



1. 70-4. 91 



2. 15, 3. 52 

 1. 59-3. 45 

 1. 67-5. 95 



1. 86-8. 67 



2. 64, 7. 24 

 1. 50-7. 93 



3. 47-4. 99 

 1. 80-6. 18 

 5. 10 



Grams 

 22.3 

 18.9 



12. 6 



14. 2 

 16. 3 



15. 4 

 14. 



14. 6 



15. 3 

 15. 2 

 15. 6 

 15. 7 



1 14. 4 (3) 



13. 



Grams 

 16. 3-30. 7 



SP81ard ___ . 



17. 4-21. 7 



Fasted rats 



Losing less than 100 grams: 



SP 8 HVO 



11. 8-15. 



SP 16 HVO 



12. 3-15. 5 



SP 8 lard 



13. 8-18. 8 



SP 16 lard . . . 



15. 1, 15. 6 



SP 8 butter 



13. 1-15. 4 



SP 16 butter ... . 



13. 0-16. 4 



Fasted and nonfasted rats 



Losing more than 100 grams: 



SP 8 HVO 



11. 3-19. 



SP16HVO-. 



14. 4, 16. 1 



SP 8 lard .. _ 



11. 7-18. 5 



SP 16 lard 



11. 7-18. 



SP 8 butter _ .. ... 



13. 9-15. 



SP 16 butter . 



13. 







1 Number in parentheses indicates number of animals when differing from that listed in column 1. 



group of animals were generally large regardless of 

 the kind or level of dietary fat. 



Rats fed diets with protein and fat of SP 



8 HVO ADJUSTED TO LEVEL IN SPE DIETS. — In 



table 33 are summarized data for kidney and liver 

 size when rats were fed modifications of the semi- 

 purified diet in which the level of fat was increased 

 to 16 percent and protein to 30 percent, or the 

 level of protein alone was increased. Most of 

 these rats had lost considerable weight before 

 death. The results obtained were similar to those 

 observed under comparable conditions with rats 

 fed SP 8 HVO diet. The smaller kidneys of the 

 rats fed SPB diet were accompanied by smaller 

 weight losses. From these data, there appeared 

 no evidence that an increase in the level of fat or 

 protein resulted in kidneys and livers comparable 

 in size to those from rats fed SPE diet, at least as 

 far as could be ascertained with moribund rats. 



Rats fed diets containing whole egg, egg 

 white, or egg yolk. — In table 34 are summarized 

 data for rats that were fed diets containing whole 

 egg, egg white, or egg yolk. Included are data 

 for 10 rats fed SPE diet when the egg in this diet 

 was dried, cooked fresh egg instead of the com- 

 mercially dried egg generally used for this diet, 

 and results for a small group of littermates fed 

 the diet of egg yolk supplemented with salt mix- 

 ture. The results for rats fed diets containing 

 egg white with HVO as the fat (SPW 8 HVO and 

 SPEW) were similar to those obtained for compar- 



able rats fed the semipurified diet (tables 22, 23, 

 25, 26). The results with SPE-fresh egg were 

 similar to those obtained on the usual SPE diet. 

 Among the animals that were losing weight, large 

 kidneys were a frequent finding with all of the 

 diets, but those from rats fed SPE diet tended to 

 be the largest. Kidneys and livers were generally 

 smaller when the diet consisted of 100 percent egg 

 yolk than when it contained a smaller amount of 

 egg yolk. The favorable response to supple- 

 mentation of Y100 with 3 percent salt mixture 

 discussed under the histological findings was also 

 apparent in the relatively small kidneys and livers 

 in these rats. 



Stock and SPE diets reversed at 250 days. — 

 In table 35 are summarized data for kidney and 

 liver weights when the diet was changed from 

 stock to SPE or the reverse at 250 days of age. 

 The kidney and liver weights of the 250-day-old 

 rats were characteristic of those generally observed 

 with these two diets. No difference in the size 

 of these organs was observed whether the rats 

 ate a constant diet throughout life or had their 

 diets reversed. It should be remembered, how- 

 ever, that when the diets were reversed, the age 

 at death was considerably greater than when either 

 diet was fed continuously throughout life. 



BHE AND WlSTAR RATS FED SP 8 HVO AND 



SPE diets. — Differences in response to diet of 

 two strains of rats are seen in table 36, which 

 summarizes data for kidney and liver weights of 



