In nonfasted rats that were maintaining weight, 

 both kidneys and livers were larger than those in 

 comparable fasted rats. The difference between 

 the size of these organs in fasted and nonfasted 

 rats varied with diet and age. 



In moribund rats, enlarged kidneys were a 

 frequent finding on all diets, particularly when 

 weight loss exceeded 100 grams. The extent of 

 the enlargement observed varied with diet. Some 

 extremely large kidneys were obtained from rats 

 fed SPE and SPPB diets. The marked increase 

 in kidney weight that occurred with increasing 

 loss of body weight was not accompanied by a 

 comparable increase in liver weight. 



The kidneys and livers from moribund Wistar 

 rats were generally small, even on SPE diet, in 

 contrast to the results with comparable BHE 

 rats fed this diet. 



Adrenal weight 



Rats maintaining weight on stock, SP 8 

 HVO, and SPE diets. — -In table 37 are sum- 

 marized data for the weights of the adrenals from 

 rats in different age groups that had been fed 

 stock, SP S HVO, or SPE diets, and were main- 

 taining weight at the time of sacrifice. No signif- 

 icant differences were observed between the adrenal 

 weights of fasted and nonfasted rats, and the 

 results recorded are the combined data for both 

 groups of animals. 



The average adrenal weight for 98 rats fed the 

 stock diet was 19.8 mg., with a wide range of values 

 from 12.4 to 33.5. No differences were noted with 

 age, either in the average values or in the distri- 



bution within groups, except for a tendency to 

 larger adrenals in the small group of rats 700 days 

 and older. 



On SP 8 HVO diet, the average adrenal weight 

 of 20.2 mg. for 64 rats was similar to that for rats 

 fed the stock diet, and again, age appeared to have 

 little effect on the size of this organ. The body 

 weight of these rats differed on the average by 

 146 grams so that the relationship of the adrenal 

 to body weight for these two groups of animals 

 differed significantly. 



On SPE diet, adrenals tended to be larger than 

 those from rats of comparable age fed stock or SP 

 8 HVO diets. The largest average adrenal weight 

 was observed for rats 300 to 399 days of age; seven 

 of these rats had adrenals exceeding 30 mg. This 

 age group corresponds to the group previously 

 shown to have very large and damaged kidneys. 



In table 3S are summarized data for adrenal 

 weights separated according to body weight. Av- 

 erage adrenal weights tended to increase with body 

 weight on all three diets. The wide range of values 

 within groups and the relatively low correlation 

 coefficients of 0.35, 0.55, and 0.38 for stock, SP 8 

 HVO, and SPE diets, respectively, indicate that 

 factors other than body weight were also in- 

 fluencing the weight of this organ. 



Rats losing weight on stock, SP 8 HVO, 

 and SPE diets. — -Data for the size of adrenals 

 from sick or moribund rats fed stock, SP 8 HVO, 

 or SPE diets are summarized in table 39. The age 

 groups available differ, depending upon the influ- 

 ence of these diets on survival. Adrenal size was 

 influenced appreciably by the extent of weight loss 



Table 37. — Adrenal weights of rats maintaining weight at different ages on stock, SP 8 HVO, and SPE diets 





Rats 



Average 

 age 



Average 



body 



weight 



Adre 



lal weight 



Adrenals weighing — 



Diet and age of rats (days) 



Average 



Range 



Less than 

 15.0 mg. 



15.0 to 

 19.9 mg. 



20.0 to 

 29.9 mg. 



30.0 mg. 

 and over 



Stock: 



Less than 200 



Number 

 19 

 24 

 13 

 13 

 12 

 12 

 5 

 98 



5 



12 



31 



7 



9 



64 



5 

 25 

 34 

 14 



9 

 87 



Days 

 151 

 249 

 381 

 449 

 538 

 652 

 844 

 389 



154 

 250 

 337 

 457 

 550 

 349 



154 

 270 

 336 

 455 

 527 

 345 



Grams 

 390 

 454 

 452 

 475 

 493 

 468 

 468 

 451 



524 

 518 

 614 

 609 

 677 

 597 



524 

 599 

 616 

 621 

 637 

 609 



Mg. 

 18.9 

 19. 2 

 19. 7 



19. 6 



20. 1 

 20. 3 

 25. 6 

 19.8 



19.2 

 18.0 

 21.0 

 19.9 

 21.0 

 20. 2 



20. 8 

 20. 4 

 27.0 

 23. 3 

 23.0 

 23.7 



Mg. 



12. 4-23. 6 



14. 0-24. 5 



13. 6-24. 4 



15. 4-24. 6 



13. 7-25. 8 



14. 5-26. 

 17. 9-33. 5 



12. 4-33. 5 



14. 3-21. 2 



13. 8-24. 3 



14. 3-32. 7 

 11. 1-27. 4 



15. 4-26. 

 11. 1-32. 7 



19. 8-21. 8 

 14. 8-27. 7 

 17. 1-55. 3 

 17. 1-29. 



16. 9-28. 4 

 14. 8-55. 3 



Percent 

 11 

 8 

 8 

 

 17 

 8 

 

 8 



20 

 8 

 3 



14 

 

 6 





 4 

 

 

 

 1 



Percent 

 53 

 50 

 46 

 46 

 25 

 58 

 20 

 46 



20 

 67 

 45 

 29 

 33 

 44 



20 

 40 

 6 

 14 

 33 

 21 



Percent 

 37 

 42 

 46 

 54 

 58 

 33 

 60 

 45 



60 

 25 



48 

 57 

 67 



48 



80 

 56 

 74 

 86 

 67 

 71 



Percent 

 



200 to 299 







300 to 399 







400 to 499 . . 







500 to 599 







600 to 699 







700 and over 



20 



Average — all . 

 SP 8 HVO: 



Less than 200 



1 

 



200 to 299 







300 to 399 



3 



400 to 499 







500 to 599 







Average — all 



SPE: 



Less than 200 _. 



2 

 



200 to 299 







300 to 399 



21 



400 to 499__ - _____ 







500 to 599 







Average — all 



7 



52 



