Adrenal weight and kidney damage. — -A 

 tendency for large adrenals to be associated with 

 damaged kidneys is seen in table 40. When 

 adrenals weighed less than 25 nig. there was little 

 evidence of kidney damage in rats that were main- 

 taining weight on stock or SP S HVO diets. In 

 the few rats with adrenals exceeding 25 mg., some 

 kidney damage was generally observed. 



In rats fed SPE diet, kidney damage was 

 apparent in several rats with adrenals weighing 

 less than 25 mg., and the extent of the damage 

 tended to increase with the size of this gland. 

 In rats that were losing weight at the time of 

 sacrifice, the extent of the degenerative changes in 

 the kidneys tended to parallel adrenal size. 



Large adrenals were observed occasionally on all 

 diets, accompanied by kidneys showing little or 

 no damage. These results suggest that adrenal 

 weights may be reflecting the health of the rat and 

 that the apparent parallelism with kidney damage 

 may be the result of the high incidence of renal 

 disease in these rats. 



Rats fed SPM, SPB, _ and SPPB diets.— 

 Limited data on adrenal size in rats maintaining 

 weight on SPM, SPB, or SPPB diets are sum- 

 marized in table 41. The adrenals were similar 



in size with all three diets and did not differ 

 appreciably from those in rats of comparable body 

 weight fed SP 8 HVO diet. They represented 

 3.3 mg./lOO g. of the body weight, a value con- 

 siderably lower than that obtained for the smaller 

 rats fed the stock diet (table 38). 



In moribund rats (table 42), adrenals tended to 

 be large even when weight loss was less than 100 

 grams. Seventy percent of the adrenals from rats 

 500 days and older fed SPB or SPPB diets ex- 

 ceeded 30 mg. "When weight loss was more than 

 100 grams, adrenals were large, regardless of age 

 or diet, except for the tendency to smaller adrenals 

 in the rats fed SPM diet that were less than 500 

 days old. 



Rats fed other experimental diets. — In 

 table 43 are summarized data for adrenal weights 

 of rats fed all other experimental diets. The 

 results are for moribund rats except for a group fed 

 SPW 8 HVO diet, in which egg white replaced the 

 casein and lactalbumin of the semipurified diet, 

 and a group fed egg yolk with or without mineral 

 supplementation. Because of the limited amount 

 of data for most of these diets, the results are 

 recorded as average values without separation by 

 weight loss. There was considerable variation in 



Table 40. — Adrenal weight in relation to extent and kind of kidney damage in rats maintaining or losing 



weight on stock, SP 8 HVO, or SPE diets 



Weight status, diet, and adrenal weight (mg.) 



Rats 



Average 

 adrenal 

 weight 



Histological rating fc 

 damage 



r kidney 





Hyalin 



Cystic 



Glomerular 



Rats maintaining weight: 

 Stock: 



Less than 20.0 



20.0 to 24.9 



Number 

 46 

 31 

 6 



22 



16 



2 



16 

 32 

 15 



3 



4 



7 

 8 

 5 



12 



8 



12 



15 



9 



3 

 15 

 33 

 56 



28 



Mg. 

 17. 2 

 22. 4 



26. 4 



16. 6 



21. 9 

 26.7 



IS. 3 



22. 6 



27. 1 



17. 6 

 22. S 

 27.7 

 34.9 

 48. 6 



17. 7 

 22. 1 

 27.6 

 34. 1 

 43.9 



17.8 

 22. 5 

 27. 7 

 34. 2 

 46. 1 



Score 

 0.3 

 . 4 

 1. 5 



. 2 



. 5 

 1. 



. 8 

 1. 2 



1. 6 



.7 

 1.0 



2. 3 

 2. 

 2.6 



. 6 



.8 



1.3 



2.2 



2. 4 



1. 7 



1. 5 



2. 3 

 2. 3 



2.4 



Score 



0. 1 

 . 1 



1.0 







.2 

 





 . 2 

 . 5 



.3 



.8 



.7 



2.0 



2.2 



.3 

 

 .8 



1. 6 

 1. 9 



1.0 

 1.0 

 1. 9 

 2.9 

 2.9 



Score 

 0. 1 

 . 1 



2.5.0 and over _ . . 



1. 5 



SP S HVO: 



Less than 20.0 







20.0 to 24.9 



. 2 



25.0 and over __ 

 SPE: 



Less than 20.0 . 





 



20.0 to 24.9 







25.0 and over _ 

 Rats losing weight: 

 Stock: 



Less than 20.0 



.3 

 



20.0 to 24.9- ___ 



. 8 



25.0 to 29.9 



1. 1 



30.0 to 39.9 



2. 4 



40.0 and over 

 SP SHVO: 

 Less than 20.0 



2.8 

 . 1 



20.0 to 24.9 







25.0 to 29.9. __. 



. 6 



30.0 to 39.9 



1.5 



40.0 and over 



1.6 



SPE: 



Less than 20.0 _._ _ ... . 



.7 



20.0 to 24.9 



25.0 to 29.9 



.7 

 1.3 



30.0 to 39.9 . 



1.8 



40.0 and over _ . . 



2. 1 







54 



