Table 43. — Adrenal weights of \ 



'•atsfed other experimental diets 







Strain and diet 



Rats 



Average 

 age 



Average 



weight 



loss 



Adrena 



weight 





Average 



Range 



BHE rats 



SPE supplemented with — 



Choline, 0.5% 



Number 



22 



8 



10 



7 



9 



10 



7 



9 



8 



9 



4 



15 



7 



6 



10 



17 



9 



6 



6 



7 



6 



21 



19 



5 

 5 

 5 



3 

 3 



2 

 2 



4 

 3 



9 

 9 



9 

 9 



Days 



474 

 463 

 434 

 465 

 412 



430 

 460 

 406 

 436 

 434 

 586 

 553 

 514 

 545 

 503 

 637 

 632 

 483 

 530 

 473 

 550 

 541 

 400 



428 

 425 

 430 



250 

 249 



574 

 396 



686 

 577 



727 

 664 



703 

 456 



Grams 

 136 

 131 

 114 



180 

 128 



138 



155 



142 



129 



183 



77 



98 



109 



75 



66 



172 



118 



166 



155 



178 







129 



73 



66 

 35 



5 





 



207 

 133 



109 

 128 



106 



80 



74 

 81 



Mg. 

 33. 9 

 32.5 

 32. 6 

 30. 1 

 28.0 



32. 1 



32. 4 



33. 5 



34. 

 36. 9 



30. 8 

 34. 

 28.9 



26. 3 



29. 4 

 32.8 



31. 8 



36. 3 

 33. 2 

 44. 5 

 15. 



37. 8 

 35.4 



27. 6 

 33. 7 

 23. 



22. 9 



23. 



25.6 

 30.5 



33.4 



30. 3 



24.2 

 35.8 



31. 1 



32. 3 



Mg. 

 22. 7-53. 3 



B 12 , 0.01 mg./lOO gm . ____ 



21. 5-39. 9 



Choline, 0.5% + Bj,, 0.01 mg./lOO gm _ 



18. 6-47. 2 



B 6 , 0.5 mg./lOO gm . ______________ 



23. 6-35. 5 



Choline, 0.5% + B 6 , 0.5 mg./lOO gm ._ 



21. 8-40. 7 



Choline, 0.5%+ B 12 , 0.01 mg./lOO gm.+ B 6 , 0.5 mg./ 

 100 gm . _ 



21. 7-42. 9 



Cholesterol, 0.46%. __ ____ 



24. 0-40. 2 



Cholesterol, 1.38%___ _. _. 



25. 0-40. 9 



Ascorbic acid, 0.2% 



19-9-44. 1 



Ascorbic acid, 0.2%+ cholesterol, 0.46% . _ 



30. 2-58. 6 



SP 16 HVO 



20. 6-42. 1 



SP 8 lard 



17. 9-60. 8 



SP 16 lard 



23. 0-35. 2 



SP 8 butter. .. ... 



17. 3-40. 9 



SP 16 butter 



11. 7-60. 3 



SPa 16 HVO 



19. 0-44. 2 



SPb8HVO._ ... 



22. 0-47. 8 



SPE (fresh egg) 



18. 0-47. 7 



SPEW 



18. 6-47. 



SPEY 



32. 7-53. 3 



SPW8 HVO 



11. 4-19. 3 



E100 



23. 1-46. 



Y100 



20. 2-46. 1 



Littermates fed — 



SPE 



23. 2-32. 4 



Y100 



24. 4-50. 1 



Y97+ salt mixture, 3.0% . ....... 



18. 8-26. 6 



Diet reversal: 



Sacrificed at approximately 250 days: 



Stock _ _ __ _ _ 



17. 5-27. 4 



SPE 



20. 5-26. 2 



Continued on — 



Stock... . ...... . _ 



25. 3, 26. 



SPE 



22. 8, 38. 2 



Reversed at 250 days: 



Stock changed to" SPE _ 



23. 2-40. 2 



SPE changed to stock _. ._ 



24. 7-40. 2 



Wistar rats 

 SP 8 HVO . 



15. 9-41. 1 



SPE 



19. 0-91. 7 



BHE rats from parents fed Wistar stock diet 

 SP8HVO __ 



19. 1-48. 3 



SPE 



17. 8-46. 







somewhat smaller, 31 mg. For male rats of the 

 Slonaker strain weighing 340 grams, Addis and 

 Gray (4) obtained a value of 37 mg. According 

 to Freudenberger (70), there was little evidence 

 for strain differences between Wistar and Long- 

 Evans rats when weight differences between strains 

 were considered. Yeakel (190) compared adrenal 

 weights of rats 700 days of age and older with 

 those of young rats, and reported consistently 

 heavier adrenals in old rats whether considered in 

 terms of absolute weight or in relation to body 

 weight. 



Several reports dealing with the influence of 



diet on adrenal size have also appeared. High- 

 protein diets have resulted in larger adrenal 

 weights than were obtained with high-carbohydrate 

 diets (82, 97, 181). The response to protein from 

 the same source may vary, depending upon the 

 specific combination of dietary ingredients. Fet- 

 ter and Neidle (60) and Ingle, Ginther, and Neza- 

 mis (98) observed increased adrenal weights on 

 hig-h-fat diets, although the differences observed 

 by Ingle were small. 



There is general agreement that many kinds of 

 shock or stress result in increased adrenal size. 

 Tepperman, Engel, and Long (180) and Sayers 



56 



