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EFFECT OF STREPTOMYCIN THERAPY ON SERUM LIPID-LIPOPROTEIN PROFILES OF RABBITS 

 INFECTED WITH MYCOBACTERIUM BOVIS. Thoen, C. 0., Karlson, A. C, and Ellefson, R. D. The Journal of 

 Infectious Diseases, Vol. 127, April, 1973, pp. 408-414. (Abstract of Published Report) 



Experiments were done to determine the effect of appropriate antibiotic therapy on the increased lipids and 

 lipoproteins in serum during infection of rabbits with Mycobacterium bovis. This organism was selected because it 

 produces progressive disease consistently in rabbits and because the disease can be satisfactorily treated with 

 streptomycin. 



Lipid-lipoprotein analyses were made on whole serum and on ultracentrifuge fractions of serum by 

 electrophoresis on paper strips presoaked in albumin-barbitol buffer solution. Serum cholesterol, phospholipid- 

 phosphorus and triglyceride analyses were made using colorimetric tests. 



In rabbits infected intravenously with Mycobacterium bovis the serum lipid levels were markedly elevated in 

 17 days. Lipoprotein analysis revealed dramatic increases of very low density lipoproteins associated with 

 concomitant decreases of high density and of low density components. In untreated rabbits these changes persisted 

 until death. In animals treated with streptomycin starting 17 days after infection, the concentrations of lipids and 

 lipoproteins in serum returned to the pre-infection levels by day 30 of therapy. 



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