ENCEPHALOMYELITIS 



NATURALLY OCCURRING AND ARTIFICIALLY INDUCED EASTERN ENCEPHALOMYELITIS IN PIGS. 

 Pursell, A. R.. Peckham, J. C, Cole, J. R.Jr., Stewart, W. C, and Mitchell, Frank E. Jr. AVMA, Vol. 161, No. 10, 

 Nov.. 1972, pp. 1143-1147. (Abstract of Published Report) 



Eastern encephalomyelitis virus (EE\ ) was isolated in cell culture from the brain of a 3-week-old pig that had 

 signs of central nervous system (CNS) disturbance. The pig was from a herd of 30 sows and 200 pigs in southern 

 (Georgia. More than 160 of these pigs died during the months of November and December. Swine pox, inclusion 

 bodv rhinitis, strongyloidosis. salmonellosis, and erysipelas were also demonstrated in the herd. 



Four of the nine nursing pigs (in a litter of 11) inoculated with either the EEV isolant in cell culture fluid or 

 10 percent brain suspension developed CNS signs similar to those seen in the naturally infected pig. Brain lesions in 

 these pigs were characterized by neutrophils in perivascular cuffs and in -necrotic areas. Neither the sow nor any of 

 the remaining pigs developed clinical illness. Five pigs without clinical evidence of encephalitis developed 

 serum-neutralizing antibodies against KEY. The sow and two pigs exposed by contact did not have detectable 

 antibodies at the end of 14 davs. 



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