■ Tartar Bmatic (Anti'mony-Potassium Tartrate) 



Tartar emetic in doses as low as -2,5 mg ./kg. caused emQsisin dogs 

 and cats. Faximun results were obtained from doses of 15, to 25mg./kg., 

 no material increase in speed of ernesis being evident from doqes in 

 excess of 25 mg./kg. No positive toxic action from tartar emetic alone 

 was observed in doses as high as 160 mg,/kg,, although the death of one 

 animal was attributed to gas -^^o^intestinkl -irritation supposedly brought 

 oii'by the emetic ^-gent "f^ha-l; ciRoompaniqd a 5P mg./kg, dose o-f zinc phos- 

 phide. The only noticefible |;eac!tiQn of the ^nim'als to tartar emetic 

 aside from ernesis is a genera^ depressive effect lasting fr^Jm 12 to 24 

 •hours, during •v\rhich -time they are off feed* No discrimination on the 

 part- of ■ Alexandrine 'rats against tartar emetic was observed. 



I 'Twenty- tvj-o dogs Virere used in a wide range of experiments in which 



50 to 100 m.g./kg« qf zinc phosphide (1^ to 2-g minimum lethal dose) with 

 25 to '100 mg,/kg.-of tartar emetic were administered to them iii hamburger 

 bait.- All the dogs vomited v/ithin 57 minutes to-2 hours and 33 minutes, 

 and the -average ■ being I hour and 31 minutes,' Tv^/enty»ene survived; one, 

 although undergoing ernesis within 1 hour and 14 minutes, succumbed to 

 the poison. 



Ten dogs arid fifteen eats were fed thallium, sulphate in quantities 

 of 35 to 150 mg./kg. (1 to a.bout 4^ minimum lethal 'dose) accompanied by 

 2.5 to 112.5,mgt/kg. of tartar emetifc, both being mixed in hamburger 

 ■bait. Twenty-three of the animals vomited within from 45 minutes to 

 more than 6 hours, the average being 1 hour and 50 minutes. The tv/o 

 animals that did not vomit were cats t All 10 dogs survived, but 7 of 

 the 15 cats succumbed. . " 



Ten dogs were given 800 to ' 1>500 mg./kg* of barium carbonate (1 to 2 

 ■minimum lethal dose) with 80 to 150 mg./kg. of tartar emetic in'hamburger 

 baiti All the dogs vomited rather promptly, v/i thin 37 to 59 mintites, or 

 an average of 45 minutes.- Nine of the -ten survived; the dcg that 

 succtimbed i^vas in ill health at the beginning of the experiment. 



'It is apparent that enough tartar emetic to be effective at a single 

 dose should be used to supplomont the full minimum- lethal dose of Sach 

 of the poisons. On this basis. 4 40 mg./kg. dose of zinc phosphide 

 •" (assumed .as the minimum for that poison) vj-o«ld call- for a supplementary 

 dosa..of 15 mg../kg'» of tartar emetic. . Likav;isG> - the same quantity of' 

 .tartar emetic, vrou Id 'bg. used to supplemoht a 3f mg,/kg. dose of thallium 

 ■sulphate, and a 700 mg./kg. . dose" of barium carbonate. Those .combinations 

 .are., the "dose units" subsequontly.mdntioned, , • ' . ' . ■ 



A study was ne^-t undertaken to dotormine survival in animals 

 ingesting .1 to 5 of the dose units. , In one experiment. 30 dogs divided 

 intO; 3 _ groups, of. 10 each wore used. The first 10 dogs, in five subgroups 

 ,of-:2 each, wero fed 1 tqi 5 doso units, rospeotivoly, of zinc pho.sphide- 

 ^tartar emetic. The .10 dogs- o,f the second lot (sirdlaj"ly divided .into 

 : subgroups of 2 each) wore, given 1 to 5, dose units, respectively-, of; 

 -thallium sulphate -tartar emetic. Because of the previously observed 



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