140 
Further Results of the Hapervmental Treatment of Trypano- 
somiasis ; being a Progress Report to a Committee of the 
Royal Society. 
By H. G. Purmer, F.R.S., W. B. Fry, Captain R.A.M.C., and H. 8. Ranxken, 
Lieutenant R.A.M.C. 
(Received September 19,—Read November 3, 1910.) 
The following results are a continuation of the work of which summaries 
have already appeared in the ‘ Proceedings of the Royal Society.’* 
These experiments have been carried out with the same strain of Surra 
as was used before, at the Brown Institution, and at the Elstree Farm of the 
Lister Institute. 
Further Experiments with Antimony wpon Dogs by New Methods. 
In the last Report} we summarised the results obtained by treating dogs 
suffering from Surra with antimony. We found that in some dogs the 
subcutaneous. or intramuscular administration of antimony or of its salts 
caused inflammatory swellings and often abscesses, with much constitutional 
disturbance, and therefore, although certain good results had been obtained, 
the method seemed impracticable for the treatment of animals upon a large 
scale. We then tried the effect of «intravenous injections of the salts of 
antimony and even of the metal itself, and this would seem at present to be 
the most promising method of giving antimony, for, if the injection of the 
metal into the veins be carried out successfully no irritation is caused. If 
the salts be injected in solution the elimination is so rapid that no good 
result can be obtained in the acute form of trypanosomiasis with which we 
have been working, so the actual injection of the metal itself has been 
successfully carried out in now a large number of instances. In the last two 
Reports mentioned above experiments have been recorded with antimony 
(metal) in a state of extremely fine division, and it was shown that it was 
relatively much more powerful than the salts in its action upon 
trypanosomes, and that its effects lasted much longer than those of the salts. 
The particles of metal, which are very minute—they vary roughly from 
05 w to 2°5 w—are taken up by the leucocytes, and some compound which 
is soluble in the liquor sanguinis is apparently formed by them. We are 
* 1907, B, vol. 79, pp. 500—516; 1908, B, vol. 80, pp. 1—12, and 477—487; 1909, B, 
vol. 81, pp. 354—371. 
+t ‘Roy. Soc. Proc.,’ B, vol. 81, p. 367. 
