1910.] Hxperimental Treatment of Trypanosomiasis. 143 
The preceding Table shows in outline the results with 13 other dogs since 
treated with antimony in the method indicated. 
The last two dogs probably died from the effects of antimony, as other 
dogs at the same time died after the first dose of that particular sample. 
Dogs are particularly susceptible to both Surra and antimony, but if 
we accept negative sub-inoculations made from the organs after death 
as fair evidence of cure, this table and the previous one will work out 
as follows :— | 
In the first Dog Table (in the last Report), on this assumption, out 
of 26 dogs, 13 may be regarded as cured, and in the one above, 2 are alive 
and 7 gave negative results, that is 22 out of 39 altogether. The indications 
are also that treatment with the metal intravenously has yielded better 
results than that with the salts, either intravenously or intramuscularly. 
The technique in dogs is difficult, as only the saphenous veins in the hind 
legs are available without an operation, and the suspension of the metal 
in salt solution must be as dilute as possible. 
Intraperitoneal Injection of Antimony (Metal). 
A series of experiments on the effects of intraperitoneal injections of 
the metal has been made on rats and rabbits. Both bear the metal quite 
well in the peritoneum, and neither pain nor inflammation were caused. 
The metal rapidly disappears from the peritoneum, and after three or 
four days none can be seen. In rats, one dose of 15 milligrammes will keep 
the trypanosomes out of the blood for an average of 25 days. No los 
of weight or appetite occurred. In dogs this method is impracticable, as the 
Injection causes acute peritonitis. 
Rats Treated with Arsenophenylglycin and Antimony. 
In the last Report is an account of some experiments with arsenophenyl- 
glycin. A rat treated with one dose of arsenophenylglycin had a dose of 
lithium antimony] tartrate given to it the day before recurrence took place in 
other rats treated with arsenophenylglycin. The rat lived 222 days without 
recurrence ; and, regarded as cured, it was reinoculated and treated intra- 
peritoneally with one dose of antimony (metal): it died 32 days after, from 
a recurrence. Another rat treated with one dose of arsenophenylglycin and 
five doses of lithium antimony tartrate died of the disease: in this case the 
latter drug was not given until after recurrence took place. | 
These experiments show again that no protection is afforded by a previous 
attack, and also that the time at which treatment is begun is of importance. 
M 2 
