144 Messrs. H. G. Plimmer and others. [Sept. 19, 
New Arsene and Antimony Compounds. 
Five Surra rats were treated with a new arsenic-camphor compound 
kindly sent to us for trial by Dr. Morgan, of the Imperial College of Science. 
They died at about the same time as untreated rats, and the substance was 
found to be too irritating for use. 
Eleven Surra rats were treated with a new organic antimony compound, 
also sent to us by Dr. Morgan. This caused considerable swelling, and did 
not effect the disappearance ,of the trypanosomes. The arsenic compound 
had no effect, the antimony a small effect. Jn vitro, the latter killed the 
organisms very slowly. 
Treatment of Goats with Antimony. 
According to Musgrave and Clegg* inoculated Surra in goats is always 
fatal, and they give 18 days as the time the untreated disease runs. 
We have treated two goats with antimony. One has had three doses of 
about 80 milligrammes each of the metal suspended in egg-yolk and oil 
subcutaneously, and is living and well 15 to 16 months after inoculation. 
The other had 15 doses of 20 m. of 5 per cent. lithium antimony] tartrate, 
and later, when it became ill with nervous symptoms, four doses of 
150 miligrammes of the metal intravenously. It became paralysed and died 
236 days after inoculation. 
Inoculations into rats from organs and cerebro-spinal fluid were negative. 
Treatment of Surra Rabbits with Antimony. 
The results of treatment of rabbits with antimony have been striking. 
They were left until they were very ill with the disease, with sores on the face, 
swollen genitals, edema, eyes and nose inflamed, and unable to stand; after 
treatment all these symptoms disappeared, and their deaths were, we believe, 
due to poisoning with an impure antimony. 
The table on p. 145 sets forth the principal points. 
Inoculations made from Nos, 2, 3, and 4 into rats after death were 
negative. 
It will be noticed that after three doses of the salt there was a recurrence, 
and also after one dose of the metal, but not in those rabbits which had 
more than one dose of the metal. | 
* “Trypanosoma and Trypanosomiasis,’ 1903. 
