1910.] . Some Enumerative Studies on Malarial Fever. 173 
forms; and fever recurs only when the parasites are numerous enough to 
produce it. 
(5) We estimate from our cases that considerable continued doses of 
quinine reduced the asexual forms by 50 to 80 per cent. 
(6) There are strong reasons for supposing that the sexual forms require 
eight to ten days for development; that the often noticed long persistence of 
crescents is not due to their long life (as generally thought) but to constant 
replenishment of the stock by fresh broods; that they sometimes show a 
distinct tertian periodicity ; and that quinine does not affect them when once 
generated, but ultimately reduces their numbers by destroying the generating 
cells. The sexual forms were never seen to produce fever. 
(7) The leucocytes are below normal during febrile periods and above 
normal afterwards. The percentage of mononuclears rises greatly after 
paroxysms, and is always in excess of the normal. 
(8) Methylene blue, soamine, X-rays, and faradic and galvanic currents had 
no results in a few experiments. 
(9) The hemoglobin falls markedly with fever, but rises rapidly with 
convalescence. 
(10) The fecal urobilin shows marked correlation with the occurrence of 
fever, and is specially studied in the accompanying paper by Dr. G. C. E. 
Simpson.* 
Many other deductions may be based on our observations, but will be 
better considered after more detailed counts have been made. 
* “Roy. Soc. Proc.,’ B, vol. 83, p. 174. 
VOL. LXXXIII.—B. O 
