238 Dr. W. Yorke. <Auto-Agglutination of [ Nov. 2,/ 
Spleen.—Weight 14 ozs. Feels hard to the knife on section. Pale appearance and 
excess of fibrous tissue on cutting open. 
Portion preserved for microscopic examination in England. 
Kidneys.—Right, weight 5 ozs. Left, 6 ozs. Both were swollen, the kidney substance 
bulging from the capsule when cut into. 
Both capsules were a little adherent. | 
Cortices undiminished. The whole kidney substance appeared a little paler than 
normal. 
Portions preserved for microscopic examination in England. 
Pancreas and Suprarenals.—Normal. 
Stomach.—Slightly dilated. No gastritis. Some post-mortem staining. 
Intestines—Normal. Mesenteric and retroperitoneal glands not enlarged. 
Brain.—Calvaria normal. Weight of brain, 52 ozs. No thickening of membranes. 
Brain substance normal. Ventricles normal in size and no excess of fluid. 
Portions of cerebral cortex and cerebellum preserved for examination in England. 
(Signed) H. B. Owen, 
Medical Officer, Civil Hospital, Entebbe. 
Auto-Agglutination of Red Blood Cells in Trypanosonnasis. 
By WarRiINGTON YorRKE, M.D. 
(Communicated by Major Ronald Ross, C.B., F.R.S. Received November 2, 
1910,—Read January 19, 1911.) 
From the Runcorn: Research Laboratories of the Liverpool School of Tropical Medicine.) 
CONTENTS. PAGE 
PmiGTOMMELVOM i: dices os\santainare octane eign bacme cealoeiite casemate oste sbesonee eee eeeeere 238 
Demonstration of the Presence of Auto- and Iso-agglutinin in the Plasma 
of Experimentally Infected Animals and of a Case of Human Trypano- 
SOMMASIS| fe, cee ccm cisiieaw ens «citns pete netltagatcenent wisieioistte Tons ate ntenies ec emp meee cen ee nee 240 
Effect of Temperature on the Reaction between Agglutinin and Red Blood ~ 
Cells erence oie se eink a eRe eee ee ee one eRe else ice eich 2s e AGERE, AAAS. 241 
Spontaneous Agglutination of Red Blood Cells from which all trace of 
Serum has been removed by repeated Washing with Normal Saline 
SOMUGIOM (sks c cohen sooeeewe scene snnetaseetieeties sess sodiethacstcatinst sehen ce eee aeaeee 242 
Absorption of Auto-agglutinin from Serum by the Red Blood Cells of the 
same “Animal e340). scooter ene tpetee eM Ree a tcwic We slols sini oo b.syre:siee Se Ee eRe EEE 243 
Reversibility of the Reaction between Auto-agglutinin and Erythrocytes... 244 
Auto-agglutinin present in the Plasma of many Normal Animals............ 246 
Relation of Auto-agglutinin of Normal Blood to that present in the Blood 
of: Infected A mimals (raster cont seme see ies slsiasia’ sieitteia su lsies edelsie ee else eee Ue Ree 247 
Effect of Heaton Auto-acolitinumee secession ccc sas ss cccceeceees teneer enn eee 247 
Significance of the Phenomenon of Auto-agglutination of Red Blood Cells 
in Trypanosomal Infections. Cause of the Development of an Excess of ° 
Auto-agglutinin in these Diseases. Iso- and Hetero-agglutinin also 
present in excess in the Blood of Infected Animals. Are Auto-, Iso-, and 
Hetero-agglutinin Distinct Specific Bodies ? 
Value of the Phenomenon as a Diagnostic Sign 
Introduction.—It is now a well recognised fact that the erythrocytes in 
fresh preparations of the blood of Sleeping Sickness cases and animals 
