418 Dr. Veley and Mr. Symes. Certain Physical and [Dec. 10, 
nerve,* these drugs have also on the circulation and on the respiration 
similar and approximately equal effects, methyl stovaine being, if anything,’ 
slightly the less active of the two. 
Amyl Stovaine. 
In comparison with the two preceding drugs, small doses of amyl stovaine 
have produced (molecule for molecule) a greater fall of blood- Rees but 
distinctly less interference with respiration. 
Initial doses of 5°8 and 9°3 mgrm. per kilo. were well tolerated, and 
41 merm. per kilo. has failed to kill. The effects are neither in type nor in 
degree, those of an acutely toxic drug. We have found amyl stovaine to be 
a powerful local anzsthetic.* 
Phenyl Stovaine and Benzyl Stovaine. 
Only one observation was made in each case. With phenyl stovaine- 
a brief rise of blood-pressure preceded the invariable fall, and both drugs 
produced some dyspnea. With benzyl stovaine Traube-Hering and Cheyne- 
Stokes rhythm was noticed in the blood-pressure and respiration respectively. 
Both drugs are powerful local anesthetics, but offer no advantage over amyl 
stovaine. 
Pourneaw’s New Salt. 
As already pointed out, this body is (in chemical structure) intermediate | 
between cocaine and stovaine. In its effects, on injection, it also resembles 
both these drugs, the latter more closely than the former. Small doses may 
(or may not) produce a trifling initial rise of blood-pressure, but any such 
rise is small in comparison with the slight fall that invariably follows it. 
This fall is less than that caused by equivalent doses of the preceding drugs. 
On respiration, its effect closely resembles that of stovaine and of methyl 
stovaine, but the momentary pause is followed by closer return to the normal 
rhythm. Its effects on blood-pressure and on respiration are therefore less” 
marked than those of cocaine, stovaine, and the homologues of the latter. 
As elsewheret stated, it is a powerful local anesthetic. 
* Vide infra, p. 426. 
+ Infra, P. 427. 
