428 Mr. W. L. Symes and Dr. V. H. Veley. [ Dec. 10, 
Table VII.—Fourneau’s Salt. 
| | Time required to 
Concentration. | Temperature. block maximal Duration of block. 
stimulus. | 
WC: mins. mins 
N/100 (0°29 per cent.) ......40 15 °6 <1-0 16-0 
ING ZOO: Giseoccaeecrsaceenines ayWastees 15 °6 1°2 6°5 
2°0 : 
7:0 
2°'5 
2°0 
V. GENERAL CONSIDERATIONS, 
The records of failure of the muscular response to stimulation of its 
motor nerve (by maximal break induction shocks of constant intensity), 
conditioned by failure of conductivity in the latter, are of the same type 
with all the drugs that we have tested.* 
il 
MN 
V4 
— —_——— 
| SS 
= i SS = 
= Se ee ~ ee 
a ae 
bs — = ~———- = See -— Pe = z == = 
hoe 
eae LS ea Teeey 
Fic. 2.—Onset of Block by a Dilute (<N/300) Solution of Amyl Stovaine in Tap-water 
Saline. Prior to the arrow the nerve bath contained normal saline. 
In interpreting them, it must be borne in mind that the drugs are applied 
to the surface of the nerve, and that their rate of diffusion into the nerve 
* In addition to the local anesthetics with which this paper deals, we have also 
examined chloretone (tertiary trichlorbutyl alcohol) and yohimbine for the latter of 
which we are indebted to Dr. Waller. Both of these are credited with local anzsthetic 
properties. 
