536 Dr. M. Haaland. [Feb, 17, 
(A) Autologous Implantation. 
The tumours employed and the results obtained are :-— 
Positive. | Negative. 
51 adeno-carcinomata of mamma— 
46 subcutaneous ......... 4A, 2 
5 intraperitoneal ...... | 5 , 
2 adeno-cancroids ............ subcutaneous .......... 2 
5 squamous cell carcinomata WR re each | 5 
1 sebaceous carcinoma ...... Fa MN ss SBE | 1 | 
3 spindle-celled sarcomata... ees a ch anette Te | 3 
iimelanomayresesare see ence iy MMe ec Heac ys | 1? 
| 
Out of 59 epithelial tumours of varied histology, 57 have grown on trans- 
plantation of the cells into the same spontaneously affected animal.* Of 
non-epithelial tumours there were four, three spindle-celled sarcomata which 
gave positive results on re-inoculation, for the fourth (a melanotic tumour of 
peculiar structure and of very low power of growth) no increase was noted of 
the grafts re-inoculated simultaneously in four different places into the mouse 
in which it had arisen, although the tumour cells remained alive for four 
months. 
(B) Lnoculations into other Spontaneously Affected Animals. 
Of the tumours which have been re-implanted into the same mice in which 
they have arisen, a number have also been tested in other mice spontaneously 
attacked with cancer. The method of implantation, dose, and site were 
exactly the same as for the autologous implantations. 
Fifty-eight implantations have been made, and of them five have been 
successful. The tumours employed and the details of the results obtained, as 
compared with the results in normal mice, will be seen from table appended. 
(c) Lnoculations into Normal Mice, Young and Old. 
In all, 73 tumours have been transplanted into 7706 mice, of which 5519 
have survived four weeks; 307 tumours have been obtained, i.e. an average 
of about 5°6 per cent. 
The experiments recorded above show that, whereas the spontaneously 
attacked animal offers a much more favourable soil for the growth of its own 
tumour cells, it is very doubtful whether it offers any better conditions for 
* The success attending autoplastic implantation is not limited to tumours of the 
mouse. It affords a method for obtaining fresh material wherever difficulties arise in 
transferring the tumours to normal animals, especially valuable in the case of larger 
animals or with ulcerated tumours, and is thus practised in the laboratory. 
