54 Dr. F. W. Pavy on the Production of Glycosuria. [Nov. 25, 



design, and consists of two bellows so arranged and adapted with vulcan- 

 ized tubing connected with a canula for ligaturing into the trachea, that 

 in working the one inflates and the other exhausts the lungs. Valves 

 are provided so as to determine this result ; and with these in good order 



I have found, in common with what has been noticed by others, that 

 respiration can be so effectively performed as to sufficiently surcharge 

 the blood with oxygen to induce a state of apnoea. 



Now by means of the performance of artificial respiration with the 

 artificial-respiration apparatus referred to, I have succeeded in producing 

 strongly saccharine urine, and this with the employment of atmospheric 

 air. In one experiment upon a dog, where the artificial respiration was 

 carried on for an hour, the urine, ten minutes after its cessation, gave a 

 strong reaction of sugar. In another experiment with .the artificial re- 

 spiration continued an hour and twenty minutes, the urine, which was 

 collected ten minutes after its cessation, was also strongly charged with 

 sugar, and thirty five minutes later showed on analysis the presence of 



II grains to the fluid ounce. In each case, for the sake of precision, 

 urine was collected and tested at the commencement of the experiment, 

 and found to be free from sugar. 



I am indebted to Dr. Lauder Brunton for directing my attention to a 

 recorded existence of the production of glycosuria by the performance of 

 artificial respiration. Tieffenbach (Centralblatt fiir die medicinischen 

 Wissenschaften, 1869, p. 181), in referring to the production of glycosuria 

 in curarized rabbits subjected to artificial respiration, says that he also 

 once obtained the same result without the previous poisoning. This 

 seems to have been a mere passing observation, while my own experi- 

 ments were elicited by a train of reasoning and without the knowledge 

 of any previously published result existing. I am not disconcerted, how- 

 ever, to find that I have been thus anticipated ; for it is only with the 

 question of fact that I feel concerned ; and it is a satisfaction to learn 

 that the result 1 have obtained is confirmed by the independent obser- 

 vation of another. 



In the course of experimenting upon this subject, I discovered that the 

 inhalation of the fumes of burning puff-ball (Lycoperdon giganteum) is 

 rapidly productive of strongly marked glycosuria ; and from certain phe- 

 nomena which I observed, I at first attributed the result to an imperfect 

 dearterialization of the blood. I noticed, for instance, when a dog was 

 brought under the anaesthetic influence of puff-ball smoke that there was 

 fulness and throbbing of the arteries, that the tongue became intensely red, 

 and that the veins underneath were in a turgid state and filled with red 

 instead of dark-coloured blood. I thought I saw in these phenomena the 

 effects of a general vaso-motor paralysis, resulting in the blood being 

 allowed to flow through the capillaries without becoming properly de- 

 arterialized, in the same manner as it is known to do locally after section 

 of certain parts of the sympathetic. 



