103 



On Intravascular Coagulation in Albinoes and Pigmented 

 Animals, and on the Behaviour of the Nucleo-proteids of 

 Testes in Solution in the Production of Intravascular 

 Coagulation. 



By George P. Mudge, A.RC.Sc. Lond., F.Z.S., Lecturer on Biology at 

 London Hospital Medical College (University of London), and at the 

 London School of Medicine for Women (University of London). 



(Communicated by Dr. A. D. Waller, F.R.S. Received April 6, — Received in 

 revised form October 16, — Eead November 1, 1906.) 



CONTENTS. 



PAGE 



Part I— 



Introduction and Historical 104 



Part II— 



The Relation of Albinism and Pigmentation to Injected Nucleo-proteids 105 



(A) Albinoes Injected with Nucleo-proteid derived from Pigmented Animals 105 



(B) Albinoes Injected with Nucleo-proteid derived from Albinoes 106 



(C) Pigmented Animals Injected with "Albino" Nucleo-proteid 108 



(D) Pigmented Animals Injected with "Pigmented" Nucleo-proteid 109 



Part III— 



(A) The Relative Resistance of Albinoes and Pigmented Animals Quanti- 



tatively Determined 110 



(B) The Relative Resistance of Albinoes and Pigmented Animals to the 



Nucleo-proteids derived from the two Alternative Sources 113 



Part IV— 



(A) Variation in the Activity or Quantity of Nucleo-proteids derived from 



Testes in Different Stages of Maturity 116 



(B) Variation in the Activity of Solutions of Nucleo-proteids with Increasing 



Age 119 



Summary of Conclusions 121 



Nature of Solutions used 122 



Tables I to V 125 



The experiments described in this paper have been performed in the 

 physiological laboratories of the University of London, and my best thanks 

 are due to Dr. Augustus Waller, the Director, and to Mr. E. Legge Symes, 

 the Demonstrator in Physiology, for the many facilities that were kindly 

 placed at my service. Especially would I like to add my testimony to the 

 value of the Dubois chloroform apparatus as a means of easily and safely 

 administering chloroform to animals. 



VOL. LXXIX. — B. K 



