104 Mr. G. P. Mudge. Intravascular Coagulation [Oct. 16, 



The cost of these experiments has been defrayed from a grant of the 

 Government Grant Committee of the Koyal Society. 



Part I. — Introduction. 



The work described in this paper was undertaken in order to ascertain the 

 differences in relation to intravascular coagulation which distinguish the 

 albino and pigmented races of a species. 



There exists a considerable body of evidence tending to show that in 

 certain qualities albinoes are less constitutionally vigorous than pigmented 

 individuals (Darwin, 1899 ; Heusinger, 1846 ; Mudge, 1907 ; Twining, 1845 ; 

 Prichard, 1855). Not a few cases of the converse kind are known, however, 

 and are cited by Darwin (1899). Farabee (Farabee and Castle, 1903) has 

 stated that albino negroes are taller and broader than their pigmented fellows, 

 and we may interpret this difference as meaning some sort of physical 

 superiority. 



Quite recently we have had the experiments of Halliburton, Brodie, and 

 Pickering (1896, 1897), which show that while the albinoes intra vascularly 

 injected by them with nucleo-proteids do not clot, their pigmented fellows 

 do. Halliburton and Pickering (1897) further proved that the three 

 synthesised colloids, A, B, and C of Grimaux, similarly clotted pigmented 

 animals, but failed to do so with the albinoes used by them. Their experi- 

 ments, while thus showing that albinoes may be more resistant than 

 pigmented individuals, also apparently demonstrate the existence of a 

 fundamental distinction between albinoes and pigmented individuals in their 

 reaction towards injected nucleo-proteids. 



But the results of the experiments described in this paper lead to a 

 modification of such a conclusion, and show that two different sub-races of 

 albinoes exist ; one resembling pigmented animals, since its individuals clot 

 upon the intravascular injection of nucleo-proteids, while the individuals of 

 the other sub-race fail to clot. 



Pickering (1897, 1899) further stated that the Norway hare in its winter 

 coat reacts like an albino, but in its summer coat like a pigmented individual. 

 The Norway hare, however, is not a complete albino when in its winter coat, 

 for it has a patch of colour on its nose, at the tips of the ear pinnae and the 

 extremity of the tail, as well as possessing black eyes. The Himalayan 

 domestic breed of rabbits, with which I have experimented, are similar to 

 the Norway hare while in its winter coat, but they have pink and not black 

 eyes. They are, therefore, not wholly comparable to the Norway hare. I 

 find the Himalayan rabbits react like true albinoes. 



