1906.] in Albinoes and Pigmented Animals, etc, 105 



Paet II. — The Eelation of Albinism and Pigmentation to Injected 



NUCLEO -PROTEIDS. 



(A) Albinoes Injected with Nucleo-proteid derived from Pigmented Animals. 



Table II. 



The first question I investigated was whether albinoes invariably failed 

 to clot when injected with a nucleo-proteid derived — like that used by 

 Halliburton and Brodie — from pigmented animals. I injected (Table II) 

 43 albinoes, of which five were rats and the rest rabbits, with such a 

 nucleo-proteid. I also injected eight of the partial albinoes known as 

 Himalayan rabbits (p. 107 and Table Y). Nine different solutions,* i.e., B, H, 

 D, I, J, K, ET, 0, and T, were used, most of them while freshly made (on 

 day of preparation), but some both when freshly prepared and at stated 

 intervals of two, five, seven, or more days after preparation, exclusive of the 

 day on which they were made. The solutions were kept in an ice safe during 

 these periods, and their physical characters, such as colour, odour, alkalinity, 

 and viscosity were normal on each occasion of using. The results are shown 

 in a tabulated form in Table II for the pure albinoes, and in Table V for the 

 Himalayan rabbits. 



The majority of pure albinoes manifested more or less extensive intra- 

 vascular coagulation, the general intensity of which is shown in the sixth 

 column of the table. In four albino rabbits, the blood absolutely failed to 

 clot (experiments 26, 53, 71, and 173) ; while three gave a qualified failure of 

 such a kind that we may, I think, regard it as of the same nature as the 

 absolute failures (experiments 29, 30, and 72). In the case of the four 

 absolute failures, as in all others, the solution was injected by one of the two 

 methods described on p. 110 until death resulted, and an immediate post-mortem 

 examination failed to reveal any clots anywhere, though I very carefully 

 examined all the smallest pulmonary vessels that could be seen with the 

 unaided eye, in addition to the main systemic and portal veins. In the three 

 qualified cases, no clots comparable to those produced in a typical intra- 

 vascular coagulation were found ; for these latter clots in a typical case are 

 strands of the form of the containing vessels and are red in colour. The clots 

 which were found in these qualified cases were not red, but colourless, and 

 they were not of the form of the containing vessel, but mere flocculi or flecks. 

 Moreover, they never occurred in the veins, but always in the cavity of the 

 right ventricle, and in two instances attached to the chorda? tendinese, and in 

 the other lying in the apex. 



Three other qualified cases (experiments 6, 65, and 70) also occurred, but 

 * As to mode of preparation of these solutions, see p. 122. 



K 2 



