106 Mr. G. P. Mudge. Intravascular Coagulation [Oct. 16, 



these, I think, must be regarded rather as very limited coagulations than as 

 failures, because the clots were red. In experiment 70, the clot was red and 

 very small, and it was attached to a few of the chordae tendinese where they 

 joined the tricuspid valve. In experiments 6 and 65 no clots occurred 

 anywhere, except that in the former case a very small red one was found in 

 the postcaval vein just before it entered the heart ; while in the latter case, 

 in addition to a few colourless fibrin specks in the right ventricle, there was 

 a semi-liquid red clot about 2 inches long formed in the postcaval vein just 

 posterior to the liver. 



(B) Albinoes Injected with Nucleo-proteid derived from Albinoes. Tables 1 



and V. 



I next ascertained whether any failures of coagulation occurred when 

 albinoes are injected with a nucleo-proteid derived from albino animals. As 

 is shown in Table 1, 24 albinoes were injected with albino nucleo-proteid, and 

 of this number four were rats and the remainder rabbits. Two Himalayan 

 rabbits were also similarly injected (Table V), but these are considered later 

 (p. 107). Seven different solutions were used, i.e., A, C, F, L, M, P, and S 

 (p. 122). In most of these experiments the solution was freshly made, but 

 in a few of them it was two or seven days old. In no case was there any 

 condition which may be termed an absolute failure of coagulation. In 

 experiment 140 there is the nearest approach to a qualified failure, for the 

 only definite clotting which occurred was in the right ventricle, where a small, 

 colourless, fibrin flocculus was formed. Careful examination of the smallest 

 pulmonary vessels, i.e., those just visible to the naked eye, showed, however, 

 that the blood appeared to be viscous and forming a kind of liquid clot. It 

 was impossible to decide definitely, owing to the smallness of the vessels. 

 Certainly, in the vessels large enough to allow of a definite observation, the 

 blood was neither clotted nor viscous. Experiment 165 helps us in a measure 

 to interpret the results of the experiment just described. In this rabbit a 

 few colourless fibrin clots were found in the right ventricle, as in rabbit 140, 

 but, in addition, there were also a few red clots in the smaller branches of 

 the pulmonary vessels, though the main vessels contained none. In experi- 

 ment 80, the pulmonary vessels contained no clots, neither did any of the 

 systemic or portal veins, but in the right ventricle there was a mixture, not 

 intermingled, of colourless fibrin clots with the ordinary red clots. 



These experiments justify the conclusion that when albinoes are injected 

 with nucleo-proteid derived from albino animals, no absolute failure of 

 coagulation occurs, such as happens in a certain percentage of cases when 

 they are injected with nucleo-proteids derived from pigmented animals. 



