1906.] in Albinoes and Pigmented Animals, etc. 107 



Doubtless, in the case of experiments 80 and 165, a much more extensive 

 coagulation would have resulted had larger doses been injected ; and the 

 fact that coagulation occurred at all, with the formation of the ordinary red 

 clots, with the minute doses used, is evidence that the animals were susceptible 

 to the coagulative properties of the nucleo-proteid, and possibly the same 

 consideration holds for experiment 140 ; the doubtfully viscous nature of the 

 blood may have become a definite coagulation had a larger dose been injected. 

 But even if we assume that in this rabbit the pulmonary blood in the smallest 

 vessels was not viscous, the case still remains one of qualified and not of 

 absolute failure ; for the right ventricle contained colourless fibrin clots. 



Thus, when albino rabbits are injected with " pigmented " nucleo-proteid, 

 about 9 per cent, of absolute failures occur, and also about 7 per cent, of 

 qualified failures. But when they are injected with " albino " nucleo-proteid 

 no absolute failures occur, and it is very doubtful if any qualified ones do. 



Partial Albinism {Himalayan Babbits). Table V. 



The characters of Himalayan rabbits are described on p. 104. The only 

 feature concerning them which it is necessary to note is that, with the excep- 

 tion of the pink eyes, they externally resemble the winter condition of the 

 Norway hare, in which Pickering failed to obtain intravascular coagulation. I 

 injected 10 of these rabbits, eight with " pigmented " nucleo-proteid and two 

 with " albino " nucleo-proteid (Table V). With respect to the eight rabbits, 

 in experiment 28 there was an absolute failure of coagulation, and in 

 experiment 8 a qualified failure, only a few colourless fibrin specks being 

 detected in the right ventricle. In the remaining six cases, coagulation, 

 though limited, was produced. Thus about 12 per cent, each of absolute and 

 qualified failures occur. 



The two which were injected with " albino " nucleo-proteid both clotted in 

 a pronounced fashion, though the dose injected in one case (Table V, 

 experiment 79) was very small. The number of experiments is too few to 

 enable one to positively state that none of them when thus injected fail to 

 clot. But if this should subsequently prove to be the case, and remembering 

 that a certain percentage of them fail to clot when injected with " pigmented " 

 nucleo-proteid, it is evident that Himalayan rabbits behave like pure 

 albinoes. 



The Cause of Failure to Coagulate is not due to the Solutions. 



In those cases, both with the complete and partial albinoes, where 

 coagulation failed to occur, the cause of failure is due to inherent qualities of 



