108 Mr. G. P. Mudge. Intravascular Coagulation [Oct. 16, 



the individuals and not to the solution or to environmental changes. The 

 failures have occurred with both fresh (experiments 26 and 173) and kept 

 (experiments 53 and 71) solutions. Moreover, fresh solutions may cause 

 coagulation in some rabbits (experiments 24, 25, 27, 171, 172, and 174) and 

 the same solution may yet fail in others (experiments 26 and 173). Smaller 

 doses may suffice to clot in some cases (experiments 37, 57, 68), and larger, 

 or sometimes very large doses of even the same solution fail in others 

 (experiments 30 and 71). In all cases the solution is injected until death 

 results. It is obvious that the failure to coagulate is an inherent quality of 

 the organism and is independent of any possible changing conditions of the 

 solution. 



(C) Pigmented Animals Injected with Nucleo-proteid derived from Albinoes. 



Table III 



I next ascertained if when pigmented animals are injected with " albino " 

 nucleo-proteid any failure of coagulation would occur, such as is the case 

 when albinoes are injected with " pigmented " nucleo-proteid. Twenty-nine 

 experiments under these conditions were performed and no failures of any 

 kind occurred. There are, however, three instances, i.e., experiments 136, 

 137, and 163, where the coagulation is very limited. In the first of these 

 only one small clot in one of the smallest pulmonary vessels was found, 

 though the shed blood clotted in 25 seconds. In'the other two cases only a few 

 clots could be found in the smallest pulmonary vessels. In experiment 92 the 

 smallest pulmonary vessels contained thin axillary threads of clot, and there 

 was a red clot in the apex of the right ventricle, but none elsewhere. In 

 experiment 89, the coagulation, though very limited in extent, was more 

 pronounced, for the right auricle and ventricle were full of red clot and the 

 left ventricle contained some colourless fibrin clots, but none of the veins 

 contained any. In case of the limited coagulation occurring in the rabbits 

 (136 and 137) just described, it is to be noted that death occurred when 

 a very minute dose only was injected. It is, therefore, probable that had not 

 death occurred when it did, a larger injection would have caused more 

 extensive coagulation. 



In experiments 145, 151, 162, and 169, the chief object was to ascertain 

 the degree of variation in the activity of the solution with increased age, and 

 as my solution was limited in quantity, I could not with these particular 

 individuals carry the injection far enough to produce either coagulation or 

 death, owing to a marked reduction in the strength of the solution or to idio- 

 syncrasy of the individuals. In experiments 145 and 162 the animals were 

 idiosyncratic to a marked degree. In the four experiments mentioned, the 



