1906.] in Albinoes and Pigmented Animals, etc. 109 



animals were not therefore killed by the injections, but doubtless had it been 

 possible to carry them far enough, coagulation would have occurred. In 

 experiment 170, the animal died as the result of the injection, and with the 

 typical symptoms of intravascular coagulation, but owing to the lateness of 

 the hour, a post-mortem examination could not be made. These experiments 

 do not, therefore, invalidate the conclusion that failure to clot does not occur 

 when pigmented animals are injected with albino nucleo-proteids. 



(D) Pigmented Animals Injected with Nucleo-proteids derived from Pigmented 



Animals. Table IV. 



Table IV shows the result of injecting 63 pigmented rabbits with " pig- 

 mented" nucleo-proteid. No failure, absolute or qualified, occurred. One or 

 two explanations are necessary. In experiment 34, the blood in the vessels 

 escaped coagulation, but a large red clot was present in the right ventricle ; 

 the clotting was therefore of the typical nature, though very limited in extent. 

 In experiment 157, the solution was used on the second day after its 

 preparation, and a comparison of experiments 158, 159, and 160, where the 

 solution was of the same age, with experiments 152 and 153, where it was 

 used fresh, showed that a small fall in activity had occurred. But in 

 experiment 157, a very large dose was injected without death resulting. I 

 did not carry the injection further, because my solution was running low. 

 Doubtless, had the injection been carried far enough, coagulation could have 

 been induced ; for it was not an infrequent phenomenon of these experiments 

 that animals possessing an idiosyncratic resistance to injected nucleo-proteids 

 now and then appeared and required abnormally large doses before coagulation 

 could be brought about. Experiments 168 (Table IV), 54, 71, 73, and 74 

 (Table II) were with rabbits of this kind. In some instances, as in 

 experiments 169, 170 (Table III), 75, and 76 (Table II), the large dose 

 required was due to a falling-off in the activity of the solution through age ; 

 but such cases can be distinguished from the idiosyncratic ones by the fact 

 that large doses were uniformly required in all the experiments in which the 

 particular solution of a certain age was used. And in the experiment now 

 under consideration, i.e., 157 (Table IV), there is no doubt that the failure to 

 kill is due to idiosyncrasy and that a sufficiently large dose would have 

 produced coagulation. For larger doses than 16 c.c. per kilogramme of body 

 weight have been necessary to produce such a result, as in experiments 1, 74, 

 and 170, where 21 c.c, 23 c.c, and 20 cc respectively were required to clot. It 

 may, therefore, be assumed that experiment 157 does not invalidate the 

 conclusion that pigmented animals are always clotted upon the injection of a 

 nucleo-proteid derived from pigmented animals. 



