110 Mr. G. P. Mudge. Intravascular Coagulation [Oct. 16, 



With respect to experiments 166, 167, and 168 (Table IV), the injection 

 resulted in death, with the usual symptoms accompanying death from intra- 

 vascular coagulation, but I had not time to make a post-mortem examination 

 in these cases. These experiments, in fact, were made for another purpose, 

 i.e., to ascertain the variation in strength of the solution with age. 



Part III. 



(A) Relative Resistance of Albinoes and Pigmented Animals, as Measured by 

 the Mean Quantity Injected Required to Produce Intravascular Coagulation. 

 Tables I to V. 



In all my experiments the quantity of nucleo-proteid injected was measured 

 and the body weight of the animal determined before the experiment 

 commenced ; with but few exceptions the animals were obtained some days 

 before the experiments were made and were kept under uniform conditions 

 with regard to time of feeding ; so that differences in body weight were not 

 due to relative differences of time between feeding and weighing. All the 

 animals injected with Solution I, i.e., 14 albinoes and 11 pigmented rabbits, 

 were kept under the same conditions for an interval of six weeks. 



The experiments were divided into two series. In the first, the injections 

 were continuous though slow, and were continued until death resulted, the 

 dose required and the time occupied being noted ; the mean time is approxi- 

 mately 1 minute 6 seconds for every cubic centimetre injected. This method 

 of injection I shall speak of as Method A. In the second series, very small 

 doses, usually 01 c.c, were injected every two minutes until death resulted, 

 and the total quantity injected then noted. As a rule death occurred at from 

 50 to 60 seconds after the lethal quantity had been injected. This method I 

 shall name Method B, and it is sometimes alluded to as the method of 

 incremental doses. In all cases the injection was made through one of the 

 marginal ear veins, by a syringe capable of containing 11 c.c. of solution. 

 The results of these experiments and the experimental data are giyen in a 

 tabulated form in Tables I to V, pp. 125 — 129. 



In making the comparisons between the mean dose required to kill 

 pigmented and albino animals, in either of the two series (i.e., in the series of 

 injections of albino and pigmented animals with " albino " nucleo-proteid and 

 in those with "pigmented" nucleo-proteid), we can either take the results 

 derived from each separate solution (group comparisons), or they can be 

 compared in the aggregate (final comparison). Neither one of these two 

 modes of comparison is preferable to the other ; since while in the former 

 the factors in each group are homogeneous, it follows that in the latter each 



