112 Mr. G. P. Mudge. Intravascular Coagulation [Oct. 16, 



the two means is accepted, as the alternative ratios given show, the general 

 result is the same, i.e., the albino is markedly more resistant than the 

 pigmented animal. 



An inspection of the figures in Table VI shows at once that in each group 

 of experiments, and with each solution used, whatever its age, the albinoes 

 require a larger mean dose per kilogramme of body weight in order to 

 produce death by intravascular coagulation. If the mean of all the means in 

 the above table is ascertained, it is found that for the pigmented animals it 

 is 069 c.c. or 0*98 c.c. per kilogramme of body weight, and for the albinoes 

 it is 1*36 c.c. or 1*91 c.c. The alternative figures depend upon whether the 

 lower or higher mean under Solutions J, K, P, and T for the albinoes, and 

 K, S, and T for the pigmented animals is included in the calculations. 



The albinoes thus appear to be about twice as resistant to the coagulating 

 influence of nucleo-proteids than do the pigmented animals, if the idiosyncratic 

 individuals are excluded, or rather less if they are included in the calcula- 

 tions. And, in whichever way we deal with the figures, the same result 

 comes out. For if, instead of taking the mean of the means included in both 

 Series 1 and 2, we ascertain the mean of the means in each series separately, 

 we reach the following figures : — The mean of all the means in Series 1 is 

 for pigmented animals 1*53 c.c. and for albinoes 3*32 or 4*36 c.c. per kilo- 

 gramme of body weight. The mean of the means in Series 2 is for pigmented 

 rabbits 0*320 or 0*735 c.c, and for albinoes 0*488 or 0*822 c.c. per kilogramme 

 of body weight. 



Thus by the Method A of injecting, the relative resisting power of 

 albinoes is about double that of the pigmented animals, the ratio being 

 2*16 or 2*8, and by the Method B it is less than double, the ratio being 1*52 

 in favour of the albino. But in the alternative results, under Method B, 

 i.e., those in which the idiosyncratic individuals are included, the pigmented 

 and albino individuals are about equally resistant, the ratio being 1*1 in 

 favour of the albino individuals. This result is apparent and not real, 

 and is due to the markedly idiosyncratic pigmented individual, 162, under 

 Solution S and, as it has been pointed out on p. 115, Part III (B), there can be 

 no doubt that it should be rejected. If the result of the S solution be rejected 

 altogether on both sides — for both the pigmented and albino series — the 

 result is a mean dose for the pigmented animals of 0*527 instead of 0*868, 

 and for the albinoes of 0*80 instead of 0*822 ; the ratio thus becomes 

 1*5 in favour of the albinoes. This ratio is the same as that for the whole 

 series under Method B, when all the idiosyncratic animals are excluded. 



The difference in the ratios of Series 1 and 2, i.e., 2*16 for the former and 

 1*52 for the latter, is partly due to the fact that Method A of injection 



