114 Mr. G. P. Mudge. Intravascular Coagulation [Oct. 16, 



nucleoproteid, any difference which may exist in the reaction of albinoes 

 towards nucleo-proteids derived from these two sources, can be ascertained. 

 And the same fact can be similarly ascertained for the pigmented animals. 



The mean doses required to kill albino and pigmented animals when both 

 kinds of nucleo-proteids are used in each instance may be obtained by calcu- 

 lation from Tables I to IV, or more quickly from the mean results of 

 Table VI, p. 111. Those experiments only in which the injections were made 

 by the incremental or B method, can be utilised for this purpose, because no 

 albinoes were injected by the A method with nucleo-proteids derived from 

 albinoes. And also, with but one exception, only those experiments have 

 been included in the calculations in which the solutions were used on the 

 day of their preparation ; the number of experiments in which older solutions 

 were used are not sufficient to enable more comparisons to be made. Owing 

 to the existence of a few individuals which manifested more or less marked 

 idiosyncratic resistance, it is necessary to obtain, both for the albinoes and 

 the pigmented animals, two mean results instead of one. One of these two 

 results in each case will include the idiosyncratic animals and the other will 

 not. The animals which are regarded as idiosyncratic are those in experi- 

 ments 63 and 67, Sol. K ; 141, Sol. P ; 172 and 174, Sol. T ; and 162, Sol. S ; 

 Tables I to IV and VI. 



If we now ascertain the mean dose of the " albino " nucleo-proteid 

 (Solutions L, M, P, and S) required to kill albino animals, it is 0*518 c.c. per 

 kilogramme of body weight, if the idiosyncratic animal 63 is excluded, and 

 0575 if included (Table VII). If we similarly determine the mean dose of 

 nucleo-proteid derived from pigmented animals (Solutions K, N, 0, T) neces- 

 sary to kill albinoes, it is found to be 0'435 c.c. (excluding experiment 67), or 

 1*136 c.c. including it. Thus, by rejecting the idiosyncratic individuals, the 

 mean dose of " pigmented " nucleo-proteid necessary to kill albinoes appears 

 to be smaller than that obtained from albinoes. The albino, therefore, is 

 more resistant to its own nucleo-proteids than to those obtained from 

 pigmented animals. 



The mean dose required to kill pigmented rabbits by the injection of 

 " albino " nucleo-proteid is 0*298 c.c, or 1*08 c.c. per kilogramme of body 

 weight ; the great increase due to idiosyncrasy occurs under the S solution in 

 relation to one animal only (162), and it must obviously be rejected. The 

 mean dose of " pigmented " nucleo-proteid required to kill them is 0*330 c.c. 

 if we reject the idiosyncrasies (experiments 63 and 172), and 0*777 c.c. if we 

 include them. Thus, disregarding the idiosyncrasies, the pigmented animals 

 appear to require a larger mean dose of their own nucleo-proteid to clot their 

 blood than they do of that obtained from albinoes. They are thus more 



