116 Mr. G. P. Mudge. Intravascular Coagulation [Oct. 16, 



An inspection of the table will show that the conditions of the experiments 

 were nearly, but not quite, equal. A comparison of the relative resistance of 

 albinoes and pigmented animals towards nucleo-proteids derived from both 

 albino and pigmented individuals has been made. It is obvious that the 

 nucleo-proteid solutions must be equal in every respect, except in their origin, 

 if the comparison is to be fair. But the mean weight of the glands used in 

 the preparation of the " pigmented " nucleo-proteid is 3*7 grammes, while 

 that for the glands used in the preparation of the " albino " nucleo-proteid is 

 3*35 grammes. If there should exist any difference in the activity of solutions 

 made from spermatic glands at different stages of maturity, it is obvious that, 

 .under the conditions of the experiments, the conclusions stated above would 

 possibly require slight modification. This possibility is discussed (Part IV, A, 

 p. 118). It may be stated, however, that such a modification is probably not 

 needed. 



Part IY. 



(A) Variation in the Activity or Quantity of Nucleo-proteids derived from 

 Testes in different Stages of Maturity. 



I was led to investigate, through the suggestion of other facts which I had 

 previously ascertained, and which are described in Section B, what influence 

 weight of gland (and presumably, therefore, degree of maturity) had upon the 

 activity of the solutions made from them. In Table VII are given the 

 weights of the testes (p. 115) from which the solutions used were made, and 

 it will be seen that the mean weight of all the glands used in the pre- 

 paration of the " albino " solutions was 3 '3 5 grammes, and that of glands 

 used in the preparation of the " pigmented " solutions was 3*7 grammes. If, 

 then, the heavier glands should be either more or less active in the pro- 

 duction of nucleo-proteids than the lighter ones of the younger individuals, 

 it is obvious that this slight difference in the mean weight of the glands 

 used from the albino and pigmented animals respectively, might introduce a 

 disturbing factor, and the arrangement of the experimental data available 

 (as in Table VII) in a form to show the relative resisting powers of albinoes 

 and pigmented individuals towards the two classes of nucleo-proteids, might 

 give apparent and not real results. 



Accordingly, the experimental data were arranged in a way to show what 

 was the influence of the weight of gland upon the activity of the solutions of 

 nucleo-proteids. I had no data as to the age of the rabbits from which the 

 glands were extracted, but as every gland used had been carefully weighed, 

 and the colour of the individuals from which they were obtained had been 

 recorded, I knew the weight, origin, and number of glands used in the pre- 



