1906.] 



in Albinoes and Pigmented Animals, etc. 



117 



paration of each of the solutions (p. 122). To an approximate degree of 

 accuracy, it may be assumed that weight of gland will coincide with the pro- 

 portional age of the animal from which it was extracted. 



If the results (only those obtained from the Method B of injection 

 are used) are plotted out, as in fig. 1, in such a way that the abscissae indicate 

 the weight of the glands, and the ordinates express the measure of the mean 

 dose of the solutions prepared from glands of different weights required to 

 clot the blood of either albinoes or pigmented individuals, one fact stands out 

 prominently. An examination of the figure shows that on the whole there 

 is a fall in strength of the solution as the gland increases in weight (age), 

 since a solution made from a heavy gland requires to be used in a larger mean 

 dose per kilogramme of body weight to produce intravascular clotting than 

 does one made from a lighter (younger) gland, The curves, while on the 

 whole gradually trending upwards, show, however, that the fall in strength is 

 not one without any fluctuations, and the nature of these will be considered 

 later. 



The two curves in fig. 1 very clearly show the greater resisting power of the 

 albinoes towards injected nucleo-proteids than that of the pigmented 

 individuals, for the upper curve represents the former, and the lower the 

 latter, and practically through the whole of its range, the " albino line " is 



------ — -r- 



-"■v -Z 



n-T -.Z 



05 5 * Z 2-~ p 





ov :p __ ; ; 



* fe io & fr %o^ ' &+' k ' 



Fig. 1. — Showing the progressive fall in activity of solutions of nucleo-proteids derived 

 from testes of increasing weight (age). The upper line is for albino animals, and the 

 lower line for pigmented individuals. The nature of the solution used (p. 122) is 

 indicated by the large letters, and its origin, i.e., whether from glands of pigmented 

 or albino individuals, is shown by the small index letters P and A respective^. The 

 abscissae show the weight of the glands in grammes, and the ordinates the amount 

 of injection in cubic centimetres per kilogramme of body weight necessary to kill by 

 intravascular coagulation. 



higher than the " pigmented line." The solutions are the same for both 

 varieties of rabbits throughout. The two curves are constructed from all the 

 results ; that is, the mean doses of the solutions of both " pigmented " and 

 " albino " nucleo-proteids are used together. In the figure, the solutions are 

 indicated by their reference letters, and the small letter to the upper and 

 right side of them, shows whether it is a solution of a " pigmented " or 

 " albino " nucleo-proteid. 



