120 Mr. G. P. Mudge. Intravascular Coagulation [Oct. 16, 



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Fig. 3. — Curves showing the fluctuation in activity of solutions of nucleo-proteids with 

 increasing period of keeping. The abscissae show the age in days of the solutions, 

 and the ordinates the amount of the injection in cubic centimetres of the solution per 

 kilogramme of body weight to produce death by intravascular coagulation. The 

 solutions used (cp. p. 122) are indicated by the letters attached to the curves. The 

 curves marked I A and I p are for albinoes and pigmented individuals respectively. 

 The curves for O and P are for pigmented individuals only. 



The behaviour of Solutions I, 0, and P is graphically represented in 

 fig. 3. With Solution 0, the mean dose required to clot on the day of its 

 preparation was 0*24 c.c. per kilogramme of body weight ; on the second 

 day afterwards (third day old solution) the activity had fallen, and a mean 

 dose of 0*38 c.c. per kilogramme of body weight was required to clot ; on 

 the fifth day after preparation the strength had increased to 0*252 c.c. ; 

 this increase continued until the seventh day of preparation, when it was 



