1906.] in Albinoes and Pigmented Animals, etc. 121 



slightly stronger, i.e., 0*236 c.c., that is, nearly as active as on the day of 

 its preparation ; on the ninth day it had fallen in activity considerably 

 i.e., to 0"9 c.c, and on the 11th day the loss of strength was very great, 

 to 4*36 c.c. The same fall on the second day, with a subsequent rise in 

 strength on the fifth, is shown in a yet more marked manner by the curve 

 for Solution P. 



In the case of the I solution, for which two curves are shown, one for 

 the albino animals (I A ) and one for the pigmented animals (P), no 

 examination of its strength on the second day was made. But for both 

 pigmented and albino animals there is a very marked rise in activity on 

 the fifth day after the preparation of the solution. In the case of the 

 albinoes the strength of the solution falls on the seventh day, but rises for 

 the pigmented animals ; this difference may be due to the fact that only 

 one pigmented rabbit was injected on the seventh day ; but, bearing in mind 

 the curve for Solution 0, it is possible it may have still retained its present 

 form if more experiments had been performed. On the 19 th day the 

 activity of the solution, when used on pigmented animals, fell very 

 markedly. It is very probable that had Solution I been tested on the 

 second day, that it would have shown, like Solutions and P, a fall in 

 activity. My experiments, however, at this period were not designed to 

 investigate this problem, and I did not consequently test the solution on the 

 second day. 



Summary of Conclusions. 



1. When albinoes are injected with a solution of nucleo-proteid derived 

 from a pigmented animal, a certain number of them, about 9 per cent., 

 absolutely fail to clot, while about 7 per cent, give a qualified clotting, the 

 remainder giving a typical intravascular coagulation of more or less 

 extensive development. 



2. When albinoes are similarly injected with a solution of nucleo-proteid, 

 but derived from albinoes, no absolute failure of coagulation occurs, and it 

 is very doubtful if any qualified ones do. The great majority clot as 

 distinctly as do pigmented individuals. 



3. When pigmented rabbits are injected with solutions of nucleo-proteids, 

 derived from albinoes or with those derived from pigmented individuals, no 

 failures of coagulation occur. 



4. The Himalayan rabbit, in respect of its reaction to injected nucleo- 

 proteids, behaves like the complete albino. This rabbit, though resembling 

 the Norway hare in its winter coat, in which condition Pickering failed 

 to obtain intravascular coagulation, differs from it in having pink 



L 2 



