The Correlation of the Ovarian and, Uterine Functions. 387 



there. I am glad also to have this opportunity of thanking Professor Kitchie, 

 of Oxford, for the interest he has taken in my work and for suggestions made 

 in the course of it. 



REFERENCES. 



1. Ainley Walker, "On some Factors in Bacteriolytic Action," 'Journal of Hygiene, 



vol. 3, p. 52, Jan., 1903. 



2. Macdonald, G. G., "On Immunity in Pneumococcal Infections," in 'Studies in 



Pathology,' edit. Bulloch, Aberdeen, 1906. 



3. Ehrlich and Morgenroth, ' Berlin Klin. Wochenschr.,' 1899, No. 1. 



4. Mainwaring, ' Journal of Infectious Diseases,' vol. 2, pp. 446 and 460. 



5. Morgenroth and Sachs, ' Berlin Klin. Wochenschr./ 1902, No. 5. 



The Correlation of the Ovarian and Uterine Functions. 

 By E. S. Caemichael, M.B., F.K.C.S.E., and F. H. A. Makshall, M.A., D.Sc. 



(Communicated by Professor E. A. Schafer, F.R.S. Received April 10, — 



Read May 30, 1907.) 



(From the Physiological Laboratory, University of Edinburgh.) 



A considerable body of evidence has been adduced in support of the 

 hypothesis that the uterus is dependent upon ovarian influence for the 

 maintenance of its structure and the discharge of its functions, and that the 

 removal of this influence at any time during reproductive life causes the 

 uterus to atrophy, besides producing a profound effect upon the entire 

 metabolism of the organism. Some writers, on the other hand (e.g., 

 Blair Bell), contend that it is the uterus which is of prime importance, 

 and observations have recently been cited pointing to the conclusion that 

 this organ exercises a control over the growth and activity of the ovaries. 

 Others, again (e.g., Bond), adopt the view that the ovaries and uterus are to 

 a very large extent inter-dependent upon each other. 



The clinical evidence brought forward by surgeons after removal of the 

 uterus and ovaries in the human subject has supported to a great extent the 

 experimental evidence of the existence of such an inter-relation. The modern 

 tendency to conserve these organs as far as possible during surgical inter- 

 ference has been brought about largely by the belief in the dependence 

 of the one organ upon the other. Important work bearing upon this subject 

 has been published recently by Zweifel (1899), Mandl and Burger (1904), 

 Bond (1906), and many other surgeons. 



It is the purpose of this paper to record a series of experiments dealing 



