1907.] Correlation of the Ovarian and Uterine Functions. 389 



of the cells being vacuolated. The muscular wall did not show much 

 degeneration, but was somewhat thinner than usual. Superficially the 

 uterus, whose size was carefully noted at the time of the operation, was 

 perceptibly smaller. 



Experiment 2. — The ovaries were removed by a mesial incision, and the 

 animal killed three and a-half months subsequently, as in the preceding 

 experiment. The glands and epithelium did not show the same degree of 

 degeneration as in the previous case. Some fibrosis was, however, clearly 

 discernable throughout the stroma. The muscles appeared to be not well 

 developed, but otherwise were fairly normal. 



Experiment 3. — The ovaries were removed from a pregnant rabbit by two 

 lateral incisions. Two days afterwards the rabbit aborted. After five and 

 a-half months the rabbit was killed. The uterus appeared very pale and 

 atrophic looking. Mammary tissue was almost non-existent. Adipose 

 tissue was super-abundant. Sections through the uterus showed that the 

 mucosa was very thin and also fibrotic, the nuclei of the stroma being few 

 and far between, excepting in the immediate neighbourhood of the 

 epithelium, just below which they were much more numerous. The glands 

 were represented by mere traces. The epithelial cells were somewhat 

 degenerated, not taking on the stain so well as normally. There were very 

 few blood-vessels. 



Experiment 4. — The ovaries of a rabbit were extirpated by means of two 

 lateral incisions a week after parturition. The animal was kept alive for 

 five and a-half months, during which time it received 22 injections of 

 commercial ovarian extract, made to determine whether this would have 

 the effect of arresting the uterine degeneration. The extract was injected 

 intra-peritoneally, one injection on an average being made every week. 

 It was found, however, that whereas sometimes the injection appeared to 

 result on the following day in a congestion of the mucous membrane of the 

 external generative organs, the atrophy of the uterus was in no way 

 prevented. Sections showed a very thin fibrotic mucosa, and a thin 

 muscular coat. As in the preceding case, the glands had almost disappeared, 

 and many of the epithelial cells were vacuolated and obviously degenerate. 

 In the cervix the changes were not so pronounced, the epithelial cells being 

 nearly normal in appearance. 



Experiment 5. — The ovaries were removed by two lateral incisions. The 

 rabbit was killed six and a-half months subsequently. Very pronounced 

 changes had taken place. The uterine stroma was extremely fibrotic, and 

 contained no glands. The epithelium was much attenuated, the nuclei 

 having failed to take up the stain to the usual extent. A few very small 



