398 Development and Regeneration of Bone. 



to grow in the midst of lacerated muscles by the mechanical distribution of 

 osteoblasts. Observation. Eiders Bone. Suggestion as to the production of 

 myositis ossificans. 



(7) Can shavings of nude bone grow on being placed between muscles in 

 a gap in the continuity of the shaft ? Experiment and result seven weeks 

 after show that not only do they grow, but that they also proliferate to a 

 very marked extent. 



Is there any direct evidence to show that transplanted living bone actually 

 grows and proliferates instead of forming, like blood clot, a passive framework 

 for the granulation tissue to penetrate, which framework will then become 

 absorbed ? There is, as may be illustrated (8) in an instance of bone grown 

 in sponge filled with granulation tissue. 



(9) To test the osteogenic power of bone cells constituting the shaft oiT 

 a long bone, they were grown inside of a glass tube. Eesult. 



(10) Intra-human transplantation of bone. Result 28 years after. Data 

 are obtained from this experiment as to the growth of the humerus 

 from the proximal and distal epiphyseal cartilages respectively. Also as to 

 interstitial osseous increase — evidence of the increase in length of the 

 diaphysis from the epiphyseal cartilage toward which the nutrient 

 vessel runs. 



