1907.] On Globylw$. 417 



(G.BS + HOH = G.HOH + BS). Therefore they are stable only in presence 

 of a large excess of salt. Hence the solvent power of salts is from 200 to 500 

 times less than that of acids or alkalies. Hence, also, the presence of the 

 globulin lowers the electric conductivity of the salt to only a small extent 

 (2 to 6 per cent.). 



A double salt of the form AB.CD. ionises according to AB.CD ^2 AB.C + D. 



I have never succeeded in detecting any trace of such ionisation in the 

 case of globulin and neutral salts ; possibly owing to the extreme instability 

 of the ions. The proteid does not move in an electric field, and it seems to 

 take no part in the electric transport. 



Owing to the insolubility of the dissociation products, the globulin can be 

 precipitated from its solution with neutral salts by simple dilution. No 

 degree of dilution will precipitate globulin from solution in dilute acid 

 or alkali. 



The compounds of globulin and alkalies (GB) are more readily dissolved 

 by neutral salts than is simple globulin. Compounds of globulins and acids 

 are insoluble by neutral salts, being decomposed with liberation of the acid. 



If on the analogy of an amido acid a globulin combines owing to the 

 presence of the NH 2 and the COOH group, then it forms salts with alkalies 

 by replacement of hydrogen, and with acids by the change of the trivalent 

 nitrogen of the amido group to the pentavalent form. 



H2 H2 



i. K(® n +NaOH = E<^ A +HOH. 

 X °<OH C <!k 



H 2 H 2 



11. 



. 'i " H 



K<C N n +HC1 = K/ N< C1 . 



XC <0H Vg H 



Where, then, does the neutral salt link on ? 



There are two possible places — the unsatisfied valencies of the nitrogen, or 

 the unsatisfied valencies of the upper O of the COOH group. According to 

 the oxonium theory, O has a maximum valency 0=, but 0= is much less 

 stable than NH ; therefore, one would expect the linkage to be by the amide 

 group — 



H2 H 2 



II ';l N a 



iii. B<f N n +NaCl =E/ N< C1 . 



Xc <oh Vr 



OH 



