Observations on the Life-history of Leucocytes. 491 



Ca = 20-9. Calculated for (CiHsOs^Ca.HA C = 21-0. The free acid melts 

 at about 100° C. 



Examination for Carbohydrates. — Sugars seemed to be absent. A small 

 quantity, however, of a mucilaginous carbohydrate similar to gastrolobin was 

 separated. 



Owing to the reported presence of quercitrin and saponin bodies, by Dunstan 

 and Stockman respectively, special search was made for these bodies, but with 

 negative results. 



Observations on the Life-history of Leucocytes. Part LI. — On the 



Origin of the Granules. 



By C. E. Walker, Assistant-Director of the Cancer Eesearch Laboratories, 



University of Liverpool. 



(Communicated by Prof. C. S. Sherrington, F.E.S. Eeceived August 2, 1906, — 



Eead February 7, 1907.) 



[Plate 5.] 



The granules that are so frequently found in leucocytes* generally seem 

 to lie scattered quite irregularly in the cytoplasm of the cell in which they 

 occur. It is possible, in the case of the leucocytes found in the spleen, 

 lymphatic glands, and the blood of mammalia, that there never is any ordered 

 arrangement of the granules. In the bone-marrow, however, where leucocytes 

 containing granules are often extremely numerous, a section of properly 

 preserved material will show that the granules in a large proportion of these 

 cells are arranged in a more or less definite manner. The granules in these 

 are, as a rule, oval in shape, and are seen to lie in sequence close to each 

 other, so that a line drawn through their long axes would appear as a thread 

 or wire coiled up irregularly in the cytoplasm of the cell (fig. 1). Given 

 this line connecting them, the granules would exactly simulate beads threaded 

 on a wire bent into irregular curves, and put into a small spheroidal space. 

 There are many gradations in the regularity of this arrangement of the 

 granules. It varies from the mere suggestion of some of them having been 

 strung together to very definite order, and the joining of several end to end 

 (%• 2). 



There are, again, other cells in which a large number of the granules are 



* As in a previous communication (" Observations on the Life-history of Leucocytes," 

 'Koy. Soc. Proc.,' B, voL 78, p. 53), the term "leucocyte " is used in the widest possible 

 sense, and is intended to include all the wandering nucleated cells of the body. 



VOL. LXXIX. — B. 2 N 



