510 



Messrs. H. G. Plimmer and J. D. Thomson. • [July 20. 



Table I. — Nagana Rats treated with Atoxyl and Succinimide of Mercury 

 Average duration of untreated disease, 5*5 days. 







Quantity 



Quantity of 









No. 



Weight. 



of 5 p. c. 

 atoxyl. 



succinimide 

 of mercury. 



Recurrences. 



Lived. 







grammes. 



c.c. 



milligrammes. 





days. 





1 



175 



2-4 



1-5 



2 



23 



Had young on 20th day. 



2 



210 



2-85 



1-75 



1 



30 



Did not die of disease. 



3 



250 



2 1 



2 5 



1 



28 



Kidneys degenerated. 



4 



200 



2-1 



2 75 







— 



Living 143 days. 



5 



175 



2-0 



0-75 



1 



27 



Did not die of disease. 



6 



150 



1-8 



1-25 







— 



Living 140 days. 



7 



200 



1-8 



1 25 







— 



Living 136 days. 



8 



150 



2-75 



2-0 



6 



79 





9 



175 



2-6 



1-25 







22 



Succinimide given too long 

 after the atoxyl. 



10 



175 



3-0 



1-25 



1 



— 



Living 92 days. 



11 



125 



1-8 



0-8 







38 





12 



200 



1-2 



0-75 



1 



— 



Living 85 days. 



13 



160 



2-8 



0-75 



3 



36 





14 



210 



4-5 



1-75 



4 



59 





15 



175 



1-75 



0-5 







— 



Living 78 days. 



16 



190 



1 4 



0-25 







— 



Living 75 days. 



17 



200 



4-1 



1-75 



4 



42 



Trypanosomes plentiful at 

 time of death, probably 

 atoxyl-proof. 



18 



175 



6 35 



2-0 



7 



107 



This rat had 5 minims, of 

 Donovan's solution on 

 the initial appearance of 

 trypanosomes, but, as it 

 had no effect, atoxyl, 















and subsequently succin- 

 imide, were given. 



19 



160 



4-1 



75 



3 



61 





20 



150 



3 7 



0-5 



3 



44 



Given paratolylarsenic 

 acid after third recur- 

 rence, which killed the 

 rat. 



21 



150 



0-7 



0-75 







— 



Living 37 days. 



