1907.] Experimental Treatment of Trypanosomiasis in Rats. 511 



Table II. — Surra Eats treated with Atoxyl and Succinimide of Mercury 

 Average duration of untreated disease, 6'9 days. 







i Quantity 



i 

 Quantity of 





1 



1 



No. 



Weight. 



of 5 p. c. 

 atoxyl. 



succinimide 

 of mercury. 



Kecurrences. 



i Lived. 







grammes. 



c.c. 



milligrammes. 





days. 





1 



175 



1*5 



2-25 







43 



Did not die of disease. 



2 



175 



1-5 



2-25 







68 



Did not die of disease. 



3 



150 



15 



125 







44 



Did not die of disease. 



4 



200 



5-1 



2-75 



3 



63 





5 



125 



18 



1-5 







— 



Living 137 days. 



6 



125 



18 



5 







120 



Did not die of disease. 



7 



155 



1-8 



0-75 



1 



24 





8 



175 



2-45 



1-0 



1 



23 



This quantity of succin- 

 imide produced an acute 

 nephritis in this rat, with 

 necrosis of the epithe- 

 lium of the convoluted 

 tubes, and many haemor- 

 rhages. 



9 



160 



3-3 



1-0 



1 



— 



Living 91 days. 



10 



150 



3-0 



0-75 



4 



55 





11 



150 



2-4 



0-75 



2 



32 





12 



160 



2 1 



37 



1 



22 



Treatment suspended on 

 10th day. 



13 



160 



1-8 



0-25 



2 



32 



Did not die of disease. 



14 



145 



2-1 



0-75 







— 



Living 42 days. 



15 



120 



1-9 



0-5 







— 



Living 39 days. 



16 



125 



3-0 



1-0 



2 



34 



This rat had 2 c.c. iodipin 

 on 3rd day. 



1.7 



200 



4-1 



1-75 



4 



42 





18 



145 



1-05 



0-25 







— 



Living 42 days. 



19 



120 



0*95 



0-5 







— 



Living 39 days. 



20 



145 



1-05 



0-65 







— 



Living 33 days. 



21 



125 



2-1 



0-75 



3 



54 



This rat had at the out- 

 set 8 mgms. in all of 

 arsenious acid, the atoxyl 

 being given on the first 

 and subsequent recur- 

 rences. 



* 22 



155 



1-5 



1-0 



1 



32 



This rat had also initial 

 treatment with arsenious 

 acid, of which it had 

 6 mgms. in all, the 

 atoxyl being given on 

 the first recurrence. The 

 rat did not die of the 

 disease, but from injury 

 during pregnancy. 



(See also No. 8, Table III.) 



Table III gives the results of treatment with atoxyl and mercury sozoiodol, 

 from which it will be seen that the results are not so good as those with 

 succinimide of mercury. Mercury sozoiodol will not mix with atoxyl, a 

 dense precipitate being formed when the solutions are mixed. The solution 

 used was the ordinary hypodermic solution (1*5 per cent.) prepared by 

 Martindale. 



2 o 2 



